The signaling pathway of hypoxia inducible factor in regulating gut homeostasis

被引：5

作者：

Liu, Wei ^{[1
,2
]}

Fan, Xueni ^{[1
,2
]}

Jian, Boshuo ^{[3
]}

Wen, Dongxu ^{[1
]}

Wang, Hongzhuang ^{[1
]}

Liu, Zhenjiang ^{[3
]}

Li, Bin ^{[1
]}

机构：

[1] Minist Agr & Rural Affairs, Inst Anim Husb & Vet, Tibet Acad Agr & Anim Husb Sci, Key Lab Anim Genet & Breeding Tibetan Plateau, Lhasa, Peoples R China

[2] Lanzhou Univ, Sch Publ Hlth, Lanzhou, Peoples R China

[3] Jilin Univ, Sch Life Sci, Natl Engn Lab AIDS Vaccine, Changchun 130012, Peoples R China

来源：

FRONTIERS IN MICROBIOLOGY | 2023年 / 14卷

关键词：

hypoxia; HIFs; signaling pathways; inflammation; gut homeostasis; INNATE LYMPHOID-CELLS; INTESTINAL BARRIER; PROTECTS MICE; T-CELLS; HIF-1; HIF-1-ALPHA; MICROBIOTA; EXPRESSION; TUMOR; ACTIVATION;

D O I：

10.3389/fmicb.2023.1289102

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Hypoxia represent a condition in which an adequate amount of oxygen supply is missing in the body, and it could be caused by a variety of diseases, including gastrointestinal disorders. This review is focused on the role of hypoxia in the maintenance of the gut homeostasis and related treatment of gastrointestinal disorders. The effects of hypoxia on the gut microbiome and its role on the intestinal barrier functionality are also covered, together with the potential role of hypoxia in the development of gastrointestinal disorders, including inflammatory bowel disease and irritable bowel syndrome. Finally, we discussed the potential of hypoxia-targeted interventions as a novel therapeutic approach for gastrointestinal disorders. In this review, we highlighted the importance of hypoxia in the maintenance of the gut homeostasis and the potential implications for the treatment of gastrointestinal disorders.

引用

页数：12

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