ANS014004, a novel small-molecule type II c-Met inhibitor effectively overcomes clinical-resistance MET mutations and exhibits antitumor activity in preclinical models of MET-amplified non-small cell lung cancer (NSCLC) and gastric cancer

被引：0
|
作者：
Li, Gong
Shi, Hepeng
Zhang, Peilong
Li, Xiangqiu
Lan, Wenli
Li, Linna
Chung, David
Schaab, Kevin
机构：
来源：
MOLECULAR CANCER THERAPEUTICS | 2023年 / 22卷 / 12期
关键词：
D O I：
10.1158/1535-7163.TARG-23-C145
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
C145
引用
收藏
页数：2
相关论文
共 50 条
  • [21] Efficacy and safety of crizotinib in patients with advanced c-MET-amplified non-small cell lung cancer (NSCLC)
    Camidge, D. Ross
    Ou, Sai-Hong Ignatius
    Shapiro, Geoffrey
    Otterson, Gregory Alan
    Villaruz, Liza Cosca
    Villalona-Calero, Miguel Angel
    Iafrate, A. John
    Varella-Garcia, Marileila
    Dacic, Sanja
    Cardarella, Stephanie
    Zhao, Weiqiang
    Tye, Lesley
    Stephenson, Patricia
    Wilner, Keith D.
    James, Leonard Philip
    Socinski, Mark A.
    JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (15)
  • [22] Glesatinib Exhibits Antitumor Activity in Lung Cancer Models and Patients Harboring MET Exon 14 Mutations and Overcomes Mutation-mediated Resistance to Type I MET Inhibitors in Nonclinical Models
    Engstrom, Lars D.
    Aranda, Ruth
    Lee, Matthew
    Tovar, Elizabeth A.
    Essenburg, Curt J.
    Madaj, Zachary
    Chiang, Harrah
    Briere, David
    Hallin, Jill
    Lopez-Casas, Pedro P.
    Banos, Natalia
    Menendez, Camino
    Hidalgo, Manuel
    Tassell, Vanessa
    Chao, Richard
    Chudova, Darya I.
    Lanman, Richard B.
    Olson, Peter
    Bazhenova, Lyudmilla
    Patel, Sandip Pravin
    Graveel, Carrie
    Nishino, Mizuki
    Shapiro, Geoffrey I.
    Peled, Nir
    Awad, Mark M.
    Janne, Pasi A.
    Christensen, James G.
    CLINICAL CANCER RESEARCH, 2017, 23 (21) : 6661 - 6672
  • [23] Discovery of LAH-1 as potent c-Met inhibitor for the treatment of non-small cell lung cancer
    Sima, Lijie
    Wang, Zhongyuan
    Yu, Ling
    Hou, Youli
    Zhao, Dongsheng
    Luo, Bilan
    Liao, Weike
    Liu, Xinfu
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2024, 39 (01) : 2286435
  • [24] Preclinical 68Ga-EMP100 PET Imaging to quantify c-Met Expression in non-small cell lung cancer (NSCLC)
    Prignon, A.
    Rusu, T.
    Anita, R.
    Portal, C.
    Cadranel, J.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2023, 50 (SUPPL 1) : S426 - S426
  • [25] Synergistic antitumor activity of low-dose c-Met tyrosine kinase inhibitor and sorafenib on human non-small cell lung cancer cells
    Fu, Ling
    Guo, Liang
    Zheng, Yi
    Zhu, Zhenyu
    Zhang, Mingyue
    Zhao, Xiaohua
    Cui, Hongxue
    ONCOLOGY LETTERS, 2018, 15 (04) : 5081 - 5086
  • [26] Mechanism of Resistance and Novel Targets Mediating Resistance to EGFR and c-Met Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer
    Botting, Gregory M.
    Rastogi, Ichwaku
    Chhabra, Gagan
    Nlend, Marie
    Puri, Neelu
    PLOS ONE, 2015, 10 (08):
  • [27] Oncogenic KRAS mediates resistance to MET targeted therapy in non-small cell lung cancer (NSCLC) with MET mutations that induce exon14 skipping
    Suzawa, Ken
    Offin, Michael D.
    Kurzatkowski, Christopher
    Liu, Daniel
    Vojnic, Morana
    Smith, Roger S.
    Mattar, Marissa
    Khodos, Inna
    de Stanchina, Elisa
    Sabari, Joshua K.
    Lockwood, William W.
    Drilon, Alexander E.
    Ladanyi, Marc
    Somwar, Romel
    CANCER RESEARCH, 2018, 78 (13)
  • [28] Alternative Signaling Pathways as Potential Therapeutic Targets for Overcoming EGFR and c-Met Inhibitor Resistance in Non-Small Cell Lung Cancer
    Fong, Jason T.
    Jacobs, Ryan J.
    Moravec, David N.
    Uppada, Srijayaprakash B.
    Botting, Gregory M.
    Nlend, Marie
    Puri, Neelu
    PLOS ONE, 2013, 8 (11):
  • [29] Anti-EGF Antibodies Significantly Improve the Activity of MET and KRAS Inhibitors in Preclinical Models of Non-small Cell Lung Cancer (NSCLC)
    Garcia-Roman, S.
    Molina-Vila, M. A.
    Gimenez-Capitan, A.
    Jordana-Ariza, N.
    Bertran-Alamillo, J.
    d'Hondt, E.
    Rosell, R.
    JOURNAL OF THORACIC ONCOLOGY, 2022, 17 (09) : S467 - S467
  • [30] MET inhibitor, capmatinib overcomes osimertinib resistance via suppression of MET/Akt/snail signaling in non-small cell lung cancer and decreased generation of cancer-associated fibroblasts
    Zhu, Kaibin
    Lv, Zhonghua
    Xiong, Jinsheng
    Zheng, Hongshan
    Zhang, Sibin
    Jin, Hua
    Yu, Lei
    Li, Zhenzhe
    Zhang, Jixing
    Li, Chenlong
    Liang, Peng
    AGING-US, 2021, 13 (05): : 6890 - 6903
12345