PTEN loss confers resistance to anti-PD-1 therapy in NSCLC by increasing tumor infiltration of T regulatory cells

被引：3
|
作者：
Exposito, Francisco
Redrado, Miriam
Houry, Maeva
Hastings, Katherine
Molero-Abraham, Magdalena
Lozano, Teresa
Solorzano, Jose L.
Ortega, Julian Sanz
Andradas, Vera
Amat, Ramon
Redin, Esther
Leon, Sergio
Legarra, Naroa
Garcia, Javier
Serrano, Diego
Valencia, Karmele
Robles-Oteiza, Camila
Foggetti, Giorgia
Felip, Enriqueta
Lasarte, Juan J.
Paz-Ares, Luis
Zugazagoitia, Jon
Politi, Katerina
Montuenga, Luis M.
Calvo, Alfonso
机构：
来源：
CANCER RESEARCH | 2023年 / 83卷 / 07期
关键词：
D O I：
10.1158/1538-7445.AM2023-1124
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
1124
引用
收藏
页数：3
相关论文
共 50 条
  • [21] Therapeutic depletion of CCR8+ tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy
    Van Damme, Helena
    Dombrecht, Bruno
    Kiss, Mate
    Roose, Heleen
    Allen, Elizabeth
    Van Overmeire, Eva
    Kancheva, Daliya
    Martens, Liesbet
    Murgaski, Aleksandar
    Bardet, Pauline Madeleine Rachel
    Blancke, Gillian
    Jans, Maude
    Bolli, Evangelia
    Martins, Maria Solange
    Elkrim, Yvon
    Dooley, James
    Boon, Louis
    Schwarze, Julia Katharina
    Tacke, Frank
    Movahedi, Kiavash
    Vandamme, Niels
    Neyns, Bart
    Ocak, Sebahat
    Scheyltjens, Isabelle
    Vereecke, Lars
    Nana, Frank Aboubakar
    Merchiers, Pascal
    Laoui, Damya
    Van Ginderachter, Jo Agnes
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 (02)
  • [22] Resistance patterns to anti-PD-1 therapy in metastatic melanoma
    Ozgun, Alpaslan
    Sondak, Vernon K.
    Markowitz, Joseph
    CHINESE CLINICAL ONCOLOGY, 2016, 5 (06)
  • [23] CRKL dictates anti-PD-1 resistance by mediating tumor-associated neutrophil infiltration in hepatocellular carcinoma
    Xie, Peiyi
    Yu, Mincheng
    Zhang, Bo
    Yu, Qiang
    Zhao, Yufei
    Wu, Mengyuan
    Jin, Lei
    Yan, Jiuliang
    Zhou, Binghai
    Liu, Shuang
    Li, Xiaoqiang
    Zhou, Chenhao
    Zhu, Xiaodong
    Huang, Cheng
    Xu, Yongfeng
    Xiao, Yongsheng
    Zhou, Jian
    Fan, Jia
    Hung, Mien-Chie
    Ye, Qinghai
    Guo, Lei
    Li, Hui
    JOURNAL OF HEPATOLOGY, 2024, 81 (01) : 93 - 107
  • [24] Transcriptional Profiling of Neoantigen Specific T Cells in Resectable NSCLC Treated with Neoadjuvant Anti-PD-1
    Caushi, J.
    Ji, Z.
    Zhang, J.
    El Asmar, M.
    Anagnostou, V.
    Cottrell, T.
    Chan, H. Y.
    Guo, H.
    Merghoub, T.
    Wolchok, J.
    Naidoo, J.
    Marrone, K.
    Chaft, J.
    Hellmann, M.
    Gabrielson, E.
    Taube, J.
    Brahmer, J.
    Velculescu, V.
    Zhao, N.
    Forde, P.
    Pardoll, D.
    Ji, H.
    Yegnasubramanian, S.
    Smith, K.
    JOURNAL OF THORACIC ONCOLOGY, 2019, 14 (10) : S717 - S717
  • [25] PD-L1 promoter methylation mediates the resistance response to anti-PD-1 therapy in NSCLC patients with EGFR-TKI resistance
    Zhang, Yan
    Xiang, Cheng
    Wang, Yuling
    Duan, Yuanyuan
    Liu, Ci
    Zhang, Yajing
    ONCOTARGET, 2017, 8 (60) : 101535 - 101544
  • [26] PRIMING OF ANTI-PD-1/ PD-L1 THERAPY BY ANTI-METABOLITE CHEMOTHERAPEUTIC AGENTS IN NSCLC
    Lin, Chingwen
    Lin, Peiying
    Yang, Panchyr
    RESPIROLOGY, 2018, 23 : 290 - 290
  • [27] The association between monocytic myeloid-derived suppressor cells levels and the anti-tumor efficacy of anti-PD-1 therapy in NSCLC patients
    Feng, Jiuxing
    Chen, Shujing
    Li, Shuangqi
    Wu, Baitong
    Lu, Jiacheng
    Tan, Li
    Li, Jiamin
    Song, Yuanlin
    Shi, Guoming
    Shi, Yujiang Geno
    Jiang, Jinjun
    TRANSLATIONAL ONCOLOGY, 2020, 13 (12):
  • [28] High Circulating Regulatory (FoxP3+) T Cells and TGF-β Predict the Response to Anti-PD-1 Immunotherapy in NSCLC Patients
    Koh, J.
    Hur, J. Y.
    Lee, K. Y.
    Kim, M. S.
    Heo, J. Y.
    Ku, B. M.
    Sun, J.
    Lee, S.
    Ahn, J. S.
    Park, K.
    Ahn, M.
    JOURNAL OF THORACIC ONCOLOGY, 2021, 16 (03) : S544 - S544
  • [29] Nanoenabled Modulation of Acidic Tumor Microenvironment Reverses Anergy of Infiltrating T Cells and Potentiates Anti-PD-1 Therapy
    Zhang, Yu-Xue
    Zhao, Yang-Yang
    Shen, Jizhou
    Sun, Xun
    Liu, Yi
    Liu, Hang
    Wang, Yucai
    Wang, Jun
    NANO LETTERS, 2019, 19 (05) : 2774 - 2783
  • [30] Contributions of T cell dysfunction to the resistance against anti-PD-1 therapy in oral carcinogenesis
    Wen, L.
    Lu, H.
    Li, Q.
    Li, Q.
    Wen, S.
    Wang, D.
    Wang, X.
    Fang, J.
    Cui, J.
    Cheng, B.
    Wang, Z.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 1759 - 1759
12345