Rh(III)-Catalyzed Direct C-H Cyclization of N-Nitrosoanilines with 1,3-Dicarbonyl Compounds: A Route to Tetrahydrocarbazol-4-ones

被引：4

作者：

Jiao, Liulin ^{[1
]}

Zhang, Bo ^{[2
]}

Qu, Bohong ^{[1
]}

Zhai, Ruirui ^{[1
]}

Chen, Xun ^{[1
]}

机构：

[1] Hainan Med Univ, Sch Pharm, Hainan Prov Key Lab Res & Dev Trop Herbs, Key Lab Trop Translat Med,Minist Educ, Haikou 571199, Peoples R China

[2] Jiujiang Univ, Affiliated Hosp, Jiujiang 332000, Jiangxi, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 15期

基金：

中国国家自然科学基金; 海南省自然科学基金;

关键词：

INDOLE SYNTHESIS; BOND FORMATION; ANNULATION; ANILINES;

D O I：

10.1021/acs.joc.3c00714

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and efficient Rh(III)-catalyzed direct C-Hbondtandem annulation of N-nitrosoanilines with 1,3-dicarbonylcompounds through two C-H bond cleavage was developed. Thisprotocol provides a rapid access to a series of valuable tetrahydrocarbazol-4-oneswith the feature of readily available starting materials, broad functionalgroup tolerance, and in situ generation of carbene precursors. Importantly,some reaction products exhibited promising antiproliferative activityin cancer cell lines.

引用

页码：10662 / 10669

页数：8

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