Rh(III)-Catalyzed Direct C-H Cyclization of N-Nitrosoanilines with 1,3-Dicarbonyl Compounds: A Route to Tetrahydrocarbazol-4-ones

被引：4
|
作者：
Jiao, Liulin [1 ]
Zhang, Bo [2 ]
Qu, Bohong [1 ]
Zhai, Ruirui [1 ]
Chen, Xun [1 ]
机构：
[1] Hainan Med Univ, Sch Pharm, Hainan Prov Key Lab Res & Dev Trop Herbs, Key Lab Trop Translat Med,Minist Educ, Haikou 571199, Peoples R China
[2] Jiujiang Univ, Affiliated Hosp, Jiujiang 332000, Jiangxi, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 15期
基金：
海南省自然科学基金; 中国国家自然科学基金;
关键词：
INDOLE SYNTHESIS; BOND FORMATION; ANNULATION; ANILINES;
D O I：
10.1021/acs.joc.3c00714
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and efficient Rh(III)-catalyzed direct C-Hbondtandem annulation of N-nitrosoanilines with 1,3-dicarbonylcompounds through two C-H bond cleavage was developed. Thisprotocol provides a rapid access to a series of valuable tetrahydrocarbazol-4-oneswith the feature of readily available starting materials, broad functionalgroup tolerance, and in situ generation of carbene precursors. Importantly,some reaction products exhibited promising antiproliferative activityin cancer cell lines.
引用
收藏
页码：10662 / 10669
页数：8
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