Characterization of high pathogenicity avian influenza H5Nx viruses from a wild harbor seal and red foxes in Denmark, 2021 and 2022

被引：4
|
作者：
Liang, Yuan [1 ,3 ]
Hjulsager, Charlotte K. [2 ]
Jensen, Tim K. [1 ]
Hammer, Anne Sofie V. [1 ]
Ovesen, Maibritt T. [1 ]
Larsen, Lars E. [1 ]
机构：
[1] Univ Copenhagen, Dept Vet & Anim Sci, Frederiksberg, Denmark
[2] Statens Serum Inst, Dept Virus & Microbiol Special Diagnost, Copenhagen, Denmark
[3] Univ Copenhagen, Dept Vet & Anim Sci, DK-1870 Frederiksberg, Denmark
来源：
INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2023年 / 17卷 / 10期
关键词：
Denmark; high pathogenicity avian influenza; influenza A virus; mammals; wild birds; VIRULENCE;
D O I：
10.1111/irv.13208
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
In 2021 and 2022, clade 2.3.4.4b H5Nx high pathogenicity avian influenza viruses were detected in one harbor seal and in one adult and three fox cubs in Denmark. The viruses were closely related to contemporary viruses found in Europe, and some had obtained amino acid substitutions related to mammalian adaptation. Notably, the virus distribution appeared to have been different in the infected fox cubs, as one exclusively tested positive for the presence of HPAIV in the brain and the other two only in the lung. Collectively, these findings stress the need for increased disease surveillance of wild and farmed mammals.
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页数：10
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