Secreted frizzled-related proteins: A promising therapeutic target for cancer therapy through Wnt signaling inhibition

被引：4
|
作者：
Zhang, Wenqiang [1 ,2 ,3 ]
Zhang, Kexin [1 ,2 ]
Ma, Yanhui [3 ]
Song, Yixin [1 ,2 ]
Qi, Tongbing [1 ,2 ]
Xiong, Guoji [1 ,2 ]
Zhang, Yuanzhu [3 ]
Kan, Chengxia [1 ,2 ]
Zhang, Jingwen [1 ,2 ]
Han, Fang [1 ,2 ,3 ]
Sun, Xiaodong [1 ,2 ]
机构：
[1] Weifang Med Univ, Dept Endocrinol & Metab, Affiliated Hosp, Weifang 261031, Peoples R China
[2] Weifang Med Univ, Clin Res Ctr, Affiliated Hosp, Weifang 261031, Peoples R China
[3] Weifang Med Univ, Dept Pathol, Affiliated Hosp, 2428 Yuhe Rd, Weifang 261031, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 166卷
基金：
中国国家自然科学基金;
关键词：
Secreted frizzled related proteins; Cancer; Wnt signaling; Tumour; FREQUENT EPIGENETIC INACTIVATION; ANTAGONIST FAMILY GENES; PROMOTER HYPERMETHYLATION; TUMOR-SUPPRESSOR; BREAST-CANCER; SFRP GENES; EXPRESSION; PATHWAY; METHYLATION; PROLIFERATION;
D O I：
10.1016/j.biopha.2023.115344
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The Wnt signaling system is a critical pathway that regulates embryonic development and adult homeostasis. Secreted frizzled-related proteins (SFRPs) are extracellular inhibitors of Wnt signaling that act by binding directly to Wnt ligands or Frizzled receptors. SFRPs can act as anti-Wnt agents and suppress cancer growth by blocking the action of Wnt ligands. However, SFRPs are often silenced by promoter methylation in cancer cells, resulting in hyperactivation of the Wnt pathway. Epigenetic modifiers can reverse this silencing and restore SFRPs expression. Despite the potential of SFRPs as a therapeutic target, the effects of SFRPs on tumor development remain unclear. Therefore, a review of the expression of various members of the SFRPs family in different cancers and their potential as therapeutic targets is warranted. This review aims to summarize the current knowledge of SFRPs in cancer, focusing on their expression patterns and their potential as novel therapeutic targets.
引用
收藏
页数：11
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