Intact finger representation within primary sensorimotor cortex of musician's dystonia

被引:9
|
作者
Sadnicka, Anna [1 ,2 ]
Wiestler, Tobias [2 ]
Butler, Katherine [3 ,4 ,5 ]
Altenmuller, Eckart [6 ]
Edwards, Mark J. [1 ]
Ejaz, Naveed [7 ]
Diedrichsen, Jorn [7 ]
机构
[1] St Georges Univ London, Movement Disorders & Neuromodulat Grp, London SW17 0RE, England
[2] UCL, Dept Clin & Movement Neurosci, London WC1N 3BG, England
[3] Univ Plymouth, Fac Hlth, Sch Hlth Profess, Plymouth PL4 4AA, Devon, England
[4] UCL, Div Surg & Intervent Sci, London WC1E 6BT, England
[5] King Edward VIIs Hosp, London Hand Therapy, London W1G 9QG, England
[6] Hannover Univ Mus Drama & Media, Inst Mus Physiol & Musicians Med, D-30175 Hannover, Germany
[7] Univ Western Ontario, Western Inst Neurosci, London, ON N6A 3K7, Canada
关键词
task-specific dystonia; focal hand dystonia; primary somatosensory cortex; primary motor cortex; representation; homunculus; FOCAL HAND DYSTONIA; PRIMARY SOMATOSENSORY CORTEX; REPETITIVE STRAIN INJURY; MODEL; REHABILITATION; FMRI;
D O I
10.1093/brain/awac356
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Sadnicka et al. counter the idea that task-specific dystonia is the result of a disordered hand somatotopy in S1. They suggest that the representational geometry of finger maps is intact and that task-specific dystonia is instead caused by a higher-order disruption of skill encoding. Musician's dystonia presents with a persistent deterioration of motor control during musical performance. A predominant hypothesis has been that this is underpinned by maladaptive neural changes to the somatotopic organization of finger representations within primary somatosensory cortex. Here, we tested this hypothesis by investigating the finger-specific activity patterns in the primary somatosensory and motor cortex using functional MRI and multivariate pattern analysis in nine musicians with dystonia and nine healthy musicians. A purpose-built keyboard device allowed characterization of activity patterns elicited during passive extension and active finger presses of individual fingers. We analysed the data using both traditional spatial analysis and state-of-the art multivariate analyses. Our analysis reveals that digit representations in musicians were poorly captured by spatial analyses. An optimized spatial metric found clear somatotopy but no difference in the spatial geometry between fingers with dystonia. Representational similarity analysis was confirmed as a more reliable technique than all spatial metrics evaluated. Significantly, the dissimilarity architecture was equivalent for musicians with and without dystonia. No expansion or spatial shift of digit representation maps were found in the symptomatic group. Our results therefore indicate that the neural representation of generic finger maps in primary sensorimotor cortex is intact in musician's dystonia. These results speak against the idea that task-specific dystonia is associated with a distorted hand somatotopy and lend weight to an alternative hypothesis that task-specific dystonia is due to a higher-order disruption of skill encoding. Such a formulation can better explain the task-specific deficit and offers alternative inroads for therapeutic interventions.
引用
收藏
页码:1511 / 1522
页数:12
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