Distinct T cell subsets in adipose tissue are associated with obesity

被引：5

作者：

Haugstoyl, Martha E. ^{[1
,2
]}

Cornillet, Martin ^{[3
]}

Strand, Kristina ^{[1
,2
]}

Stiglund, Natalie ^{[3
]}

Sun, Dan ^{[3
]}

Lawrence-Archer, Laurence ^{[1
,2
]}

Hjellestad, Iren D. ^{[1
,4
]}

Sparrelid, Ernesto ^{[5
]}

Busch, Christian ^{[6
]}

Hjelmesaeth, Joran ^{[7
,8
]}

Hertel, Jens K. ^{[7
]}

Ponzetta, Andrea ^{[3
]}

Mellgren, Gunnar ^{[1
,2
]}

Ferno, Johan ^{[1
,2
]}

Bjorkstrom, Niklas K. ^{[3
]}

机构：

[1] Haukeland Hosp, Dept Med Biochem & Pharmacol, Hormone Lab, Bergen, Norway

[2] Univ Bergen, Dept Clin Sci, Mohn Nutr Res Lab, Bergen, Norway

[3] Karolinska Inst, Ctr Infect Med, Karolinska Univ Hosp, Dept Med Huddinge, Stockholm, Sweden

[4] Haukeland Hosp, Dept Med, Bergen, Norway

[5] Karolinska Inst, Karolinska Univ Hosp, Dept Clin Sci Intervent & Technol, Div Surg, Stockholm, Sweden

[6] Plastikkirurg1, Bergen, Norway

[7] Vestfold Hosp Trust, Morbid Obes Ctr, Dept Med, Tonsberg, Norway

[8] Univ Oslo, Inst Clin Med, Dept Endocrinol Morbid Obes & Prevent Med, Oslo, Norway

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2023年 / 53卷 / 02期

基金：

瑞典研究理事会;

关键词：

adipose tissue; multicolor flow cytometry; obesity; obesity-specific genes; T cells; IMMUNE HOMEOSTASIS; INFLAMMATION; MAINTENANCE; POPULATIONS; ACTIVATION; RECEPTOR;

D O I：

10.1002/eji.202249990

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adipose tissue inflammation is a driving factor for the development of obesity-associated metabolic disturbances, and a role of adipose tissue T cells in initiating the pro-inflammatory signaling is emerging. However, data on human adipose tissue T cells in obesity are limited, reflected by the lack of phenotypic markers to define tissue-resident T cell subsets. In this study, we performed a deep characterization of T cells in blood and adipose tissue depots using multicolor flow cytometry and RNA sequencing. We identified distinct subsets of T cells associated with obesity expressing the activation markers, CD26 and CCR5, and obesity-specific genes that are potentially engaged in activating pro-inflammatory pathway, including ceramide signaling, autophagy, and IL-6 signaling. These findings increase our knowledge on the heterogeneity of T cells in adipose tissue and on subsets that may play a role in obesity-related pathogenesis.

引用

页数：9

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