Recent advances in dual-drug co-amorphous systems

被引：9
|
作者：
Shelke, Rutuja [1 ]
Velagacherla, Varalakshmi [1 ]
Nayak, Usha Yogendra [1 ]
机构：
[1] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharmaceut, Manipal 576104, Karnataka, India
来源：
DRUG DISCOVERY TODAY | 2024年 / 29卷 / 02期
关键词：
solubility; co-amorphous systems; dual-drug co-amorphous systems; molecular modelling; crystalline drugs; stability; amorphous drugs; docking models; crystalline inhibitors; IN-VIVO BIOAVAILABILITY; PHYSICOCHEMICAL PROPERTIES; PHYSICAL STABILITY; ENHANCED DISSOLUTION; ORAL BIOAVAILABILITY; COAMORPHOUS SYSTEM; DELIVERY SYSTEMS; CLASSIFICATION; COMBINATIONS; RITONAVIR;
D O I：
10.1016/j.drudis.2023.103863
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Poor solubility of drugs and therapeutic candidates poses a significant challenge in drug research and development. Biopharmaceutical class II drugs exhibit limited absorption because of their weak solubility and high permeability. Co-amorphous systems (CAMs) have been studied widely as a way to improve the solubility of drugs. This review summarizes recent advancements in dual-drug CAMs, including improvements in formulation, manufacturing, and solid-state characterization, and highlights the importance of enhancing solubility and stability. It emphasizes the potential synergistic effects of two drugs in CAMs and explores formulation strategies and challenges related to maintaining the amorphous state. Case studies demonstrate the successful application of CAMs in combination therapies that offer improved therapeutic efficacy.
引用
收藏
页数：14
相关论文
共 50 条
  • [41] Research Progress of Co-amorphous Drugs
    Fang, Xiaoping
    Hu, Yi
    Lu, Shan
    Cao, Yan
    Chinese Journal of Pharmaceuticals, 2022, 53 (07) : 953 - 961
  • [42] Considerations on the Kinetic Processes in the Preparation of Ternary Co-Amorphous Systems by Milling
    Wang, Yixuan
    Rades, Thomas
    Grohganz, Holger
    PHARMACEUTICS, 2023, 15 (01)
  • [43] Improving physicochemical properties and pharmacological activities of ternary co-amorphous systems
    Fang, Xiaoping
    Hu, Yi
    Yang, Guangyi
    Shi, Wenfeng
    Lu, Shan
    Cao, Yan
    EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2022, 181 : 22 - 35
  • [44] Characterisation and stability of co-amorphous systems containing olanzapine and sulphonic acids
    Santos, Ines A.
    Bastos, Ana C.
    Pinto, Joao F.
    Fernandes, Ana I.
    ANNALS OF MEDICINE, 2021, 53 : S111 - S112
  • [45] Pyrazinamide-Diflunisal: A New Dual-Drug Co-Crystal
    Evora, Antonio O. L.
    Castro, Ricardo A. E.
    Maria, Teresa M. R.
    Rosado, Mario T. S.
    Ramos Silva, M.
    Matos Beja, A.
    Canotilho, Joao
    Eusebio, M. Ermelinda S.
    CRYSTAL GROWTH & DESIGN, 2011, 11 (11) : 4780 - 4788
  • [46] Solid-Liquid Equilibrium in Co-Amorphous Systems: Experiment and Prediction
    Zemankova, Alzbeta
    Hassouna, Fatima
    Klajmon, Martin
    Fulem, Michal
    MOLECULES, 2023, 28 (06):
  • [47] Mechanistic Investigation into Crystallization of Hydrated Co-Amorphous Systems of Flurbiprofen and Lidocaine
    Xu, Xiaoyue
    Grohganz, Holger
    Knapik-Kowalczuk, Justyna
    Paluch, Marian
    Rades, Thomas
    PHARMACEUTICS, 2025, 17 (02)
  • [48] The influence of co-formers on the dissolution rates of co-amorphous sulfamerazine/excipient systems
    Gniado, Katarzyna
    Lobmann, Korbinian
    Rades, Thomas
    Erxleben, Andrea
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2016, 504 (1-2) : 20 - 26
  • [49] Introduction to Pharmaceutical Co-amorphous Systems Using a Green Co-milling Technique
    Silva, Joana F. C.
    Maria, Teresa M. R.
    Silva, Pedro S. Pereira
    Silva, Manuela Ramos
    Rosado, Mario T. S.
    Eusebio, M. Ermelinda S.
    JOURNAL OF CHEMICAL EDUCATION, 2023, 100 (04) : 1627 - 1632
  • [50] Unlocking the potential of flavonoid-based co-crystal and co-amorphous systems
    Rode, Khushi
    Maji, Indrani
    Mahajan, Srushti
    Singh, Pankaj Kumar
    DRUG DISCOVERY TODAY, 2024, 29 (07)
12345