Recent advances in dual-drug co-amorphous systems

被引：9
|
作者：
Shelke, Rutuja [1 ]
Velagacherla, Varalakshmi [1 ]
Nayak, Usha Yogendra [1 ]
机构：
[1] Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharmaceut, Manipal 576104, Karnataka, India
来源：
DRUG DISCOVERY TODAY | 2024年 / 29卷 / 02期
关键词：
solubility; co-amorphous systems; dual-drug co-amorphous systems; molecular modelling; crystalline drugs; stability; amorphous drugs; docking models; crystalline inhibitors; IN-VIVO BIOAVAILABILITY; PHYSICOCHEMICAL PROPERTIES; PHYSICAL STABILITY; ENHANCED DISSOLUTION; ORAL BIOAVAILABILITY; COAMORPHOUS SYSTEM; DELIVERY SYSTEMS; CLASSIFICATION; COMBINATIONS; RITONAVIR;
D O I：
10.1016/j.drudis.2023.103863
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Poor solubility of drugs and therapeutic candidates poses a significant challenge in drug research and development. Biopharmaceutical class II drugs exhibit limited absorption because of their weak solubility and high permeability. Co-amorphous systems (CAMs) have been studied widely as a way to improve the solubility of drugs. This review summarizes recent advancements in dual-drug CAMs, including improvements in formulation, manufacturing, and solid-state characterization, and highlights the importance of enhancing solubility and stability. It emphasizes the potential synergistic effects of two drugs in CAMs and explores formulation strategies and challenges related to maintaining the amorphous state. Case studies demonstrate the successful application of CAMs in combination therapies that offer improved therapeutic efficacy.
引用
收藏
页数：14
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