A New Perspective in the Treatment of Ischemic Stroke: Ferroptosis

被引：6

作者：

Zhang, Lei ^{[1
]}

Bai, Xin Yue ^{[1
]}

Sun, Ke Yao ^{[1
]}

Li, Xuan ^{[1
]}

Zhang, Zhao Qi ^{[1
]}

Liu, Yi Ding ^{[1
]}

Xiang, Yang ^{[1
]}

Liu, Xiao Long ^{[1
]}

机构：

[1] Yanan Univ, Med Sch, Yanan 716000, Peoples R China

来源：

NEUROCHEMICAL RESEARCH | 2024年 / 49卷 / 04期

关键词：

Ischemic Stroke; Ferroptosis; Neurological Damage; Ferroptosis Inhibitors; BRAIN-INJURY; EDARAVONE DEXBORNEOL; NEURON FERROPTOSIS; REPERFUSION INJURY; CEREBRAL-ISCHEMIA; IRON; REGULATOR; PATHWAY; CANCER; FSP1;

D O I：

10.1007/s11064-023-04096-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ischemic stroke is a common neurological disease. Currently, there are no Food and Drug Administration-approved drugs that can maximize the improvement in ischemic stroke-induced nerve damage. Hence, treating ischemic stroke remains a clinical challenge. Ferroptosis has been increasingly studied in recent years, and it is closely related to the pathophysiological process of ischemic stroke. Iron overload, reactive oxygen species accumulation, lipid peroxidation, and glutamate accumulation associated with ferroptosis are all present in ischemic stroke. This article focuses on describing the relationship between ferroptosis and ischemic stroke and summarizes the relevant substances that ameliorate ischemic stroke-induced neurological damage by inhibiting ferroptosis. Finally, the problems in the treatment of ischemic stroke targeting ferroptosis are discussed, hoping to provide a new direction for its treatment.

引用

页码：815 / 833

页数：19

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