Loss of Respiratory Syncytial Virus Antibody Functions During the Peak of the COVID-19 Pandemic Mitigation Measures

被引:2
|
作者
Abu-Raya, Bahaa [1 ,2 ,5 ]
Reicherz, Frederic [1 ,2 ,3 ]
Michalski, Christina [1 ,2 ]
Paramo, Marina Vineta [1 ,2 ]
Majdoubi, Abdelilah [1 ,2 ]
Golding, Liam [1 ,2 ]
Granoski, Madison [4 ]
Stojic, Aleksandra [4 ]
Marchant, David J. [4 ]
Lavoie, Pascal M. [1 ,2 ]
机构
[1] British Columbia Childrens Hosp Res Inst, 950 West 28th Ave, Vancouver, BC V5Z 4H4, Canada
[2] Univ British Columbia, Fac Med, Dept Pediat, Vancouver, BC, Canada
[3] Univ Witten Herdecke, Childrens Hosp Datteln, Dept Pediat, Datteln, Germany
[4] Univ Alberta, Li Ka Shing Inst Virol, Fac Med & Dent, Dept Med Microbiol & Immunol, Edmonton, AB, Canada
[5] Univ British Columbia, Dept Pediat, Vancouver, BC, Canada
关键词
COVID-19; Fc-mediated function; immunity debt; RSV; RSV hiatus; RISK-FACTORS; PROTECTION; INFECTION; INFANTS; LOAD;
D O I
10.1093/jpids/piad099
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Studies have linked respiratory syncytial virus (RSV) antibody-mediated phagocytosis and complement deposition to severe RSV infection in humans. This study shows waning of these antibody functions in women of childbearing age in 2020-2021 during the implementation of COVID-19 mitigation measures, in absence of RSV circulation. These functions could be explored as correlates of protection against severe RSV disease. The waning of phagocytic and complement-mediated antibody functions associated with protection from severe respiratory syncytial virus (RSV) infection in humans, in the absence of viral circulation during the peak of implementation of COVID-19 mitigation measures in 2020-2021 indicate that these functions could be explored as correlates of protection against severe RSV disease.
引用
收藏
页码:642 / 645
页数:4
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