Multimorbidity and Serological Response to SARS-CoV-2 Nine Months after 1st Vaccine Dose: European Cohort of Healthcare Workers-Orchestra Project

被引:5
|
作者
Violan, Concepcion [1 ,2 ,3 ,4 ,5 ,6 ]
Carrasco-Ribelles, Lucia A. [1 ,3 ,4 ]
Collatuzzo, Giulia [7 ]
Ditano, Giorgia [7 ]
Abedini, Mahsa [7 ]
Janke, Christian [8 ]
Reinkemeyer, Christina [8 ]
Giang, Le Thi Thu [9 ]
Liviero, Filippo [10 ]
Scapellato, Maria Luisa [11 ]
Mauro, Marcella [12 ]
Rui, Francesca [12 ]
Porru, Stefano [13 ,14 ]
Spiteri, Gianluca [13 ]
Monaco, Maria Grazia Lourdes [13 ]
Carta, Angela [13 ,14 ]
Otelea, Marina [15 ]
Rascu, Agripina [15 ]
Fabianova, Eleonora [16 ,17 ]
Kloslova, Zuzana [16 ,17 ]
Boffetta, Paolo [7 ]
Toran-Monserrat, Pere [1 ,2 ,5 ,18 ,19 ]
机构
[1] Inst Univ Invest Atencio Primaria Jordi Gol IDIAP, Unitat Suport Recerca Metropolitana Nord, Mare De Deu De Guadalupe 08303, Mataro, Spain
[2] Germans Trias & Pujol Res Inst IGTP, Cami Escoles S-N, Badalona 08916, Spain
[3] Fundacio Inst Univ Recerca Atencio Primaria Salut, Grp REcerca Impacte Malalties Cron & Seves Traject, Barcelona 01537, Spain
[4] Inst Salud Carlos III, Network Res Chron Primary Care & Hlth Promot RICAP, Ave Monforte de Lemos 5, Madrid 28029, Spain
[5] Inst Catala Salut, Direccio Atencio Primiria Metropolitana Nord, Ctra Barcelona 473, Barcelona 08204, Spain
[6] Univ Autonoma Barcelona, Pl Civ, Bellaterra 08193, Spain
[7] Univ Bologna, Dept Med & Surg Sci, I-40138 Bologna, Italy
[8] Univ Hosp LMU, Div Infect Dis & Trop Med, Leopoldstr 5, D-80802 Munich, Germany
[9] Ludwig Maximilians Univ Munchen, Dr von Hauner Childrens Hosp, Dept Pediat, Univ Hosp Munich, Lindwurmstr 4, D-80337 Munich, Germany
[10] Univ Padua, Dept Cardiac Thorac Vasc Sci & Publ Hlth, I-35128 Padua, Italy
[11] Univ Hosp Padova, Occupat Med Unit, I-35128 Padua, Italy
[12] Univ Trieste, Dept Med Sci, Unit Occupat Med, I-34100 Trieste, Italy
[13] Univ Hosp Verona, Occupat Med Unit, I-37134 Verona, Italy
[14] Univ Verona, Dept Diagnost & Publ Hlth, Sect Occupat Hlth, I-37134 Verona, Italy
[15] Univ Med & Pharm Carol Davila, Bucharest 020022, Romania
[16] Reg Author Publ Hlth, Occupat Hlth Dept, Banska Bystrica 97556, Slovakia
[17] Catholic Univ, Fac Hlth, Publ Hlth Dept, Ruzomberok 03401, Slovakia
[18] Univ Girona, Fac Med, Dept Med, Girona 17001, Spain
[19] Inst Univ Invest Atencio Primaria Jordi Gol IDIAP, Multidisciplinary Res Grp Hlth & Soc GREMSAS 2021, Barcelona 08303, Spain
基金
欧盟地平线“2020”;
关键词
SARS-CoV-2; antibodies; IgG; humoral immunity; seroprevalence; COVID-19; vaccine; multimorbidity; healthcare workers; cohort; COVID-19; VACCINE;
D O I
10.3390/vaccines11081340
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Understanding antibody persistence concerning multimorbidity is crucial for vaccination policies. Our goal is to assess the link between multimorbidity and serological response to SARS-CoV-2 nine months post-first vaccine. We analyzed Healthcare Workers (HCWs) from three cohorts from Italy, and one each from Germany, Romania, Slovakia, and Spain. Seven groups of chronic diseases were analyzed. We included 2941 HCWs (78.5% female, 73.4% & GE; 40 years old). Multimorbidity was present in 6.9% of HCWs. The prevalence of each chronic condition ranged between 1.9% (cancer) to 10.3% (allergies). Two regression models were fitted, one considering the chronic conditions groups and the other considering whether HCWs had diseases from & GE;2 groups. Multimorbidity was present in 6.9% of HCWs, and higher 9-months post-vaccine anti-S levels were significantly associated with having received three doses of the vaccine (RR = 2.45, CI = 1.92-3.13) and with having a prior COVID-19 infection (RR = 2.30, CI = 2.15-2.46). Conversely, lower levels were associated with higher age (RR = 0.94, CI = 0.91-0.96), more time since the last vaccine dose (RR = 0.95, CI = 0.94-0.96), and multimorbidity (RR = 0.89, CI = 0.80-1.00). Hypertension is significantly associated with lower anti-S levels (RR = 0.87, CI = 0.80-0.95). The serological response to vaccines is more inadequate in individuals with multimorbidity.
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页数:13
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