Advances in probing single biomolecules: From DNA bases to glycans

被引：5

作者：

Hou, Baofei ^{[1
]}

Zhang, Teng ^{[1
]}

Yang, Huixia ^{[1
]}

Han, Xu ^{[1
]}

Liu, Liwei ^{[1
]}

Li, Linfei ^{[2
]}

Grazioli, Cesare ^{[3
]}

Wu, Xu ^{[1
]}

Jiang, Nan ^{[2
]}

Wang, Yeliang ^{[1
]}

机构：

[1] Beijing Inst Technol, Sch Integrated Circuits & Elect, MIIT Key Lab Low Dimens Quantum Struct & Devices, Beijing, Peoples R China

[2] Univ Illinois, Dept Chem, Chicago, IL USA

[3] CNR, Ist Officina Mat, IOM, Trieste, Italy

来源：

INTERDISCIPLINARY MATERIALS | 2023年 / 2卷 / 04期

基金：

中国国家自然科学基金;

关键词：

atomic-scale probing; biomolecules; scanning probe microscopy; structure; visualization; ATOMIC-FORCE MICROSCOPY; ION-BEAM DEPOSITION; MOLECULAR-STRUCTURE; CHIRAL RECOGNITION; AMINO-ACIDS; SURFACE; SOFT; TREHALOSE; GRAPHITE; INSIGHTS;

D O I：

10.1002/idm2.12106

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Imaging biomolecules in real space is crucial for gaining a comprehensive understanding of the properties and functions of biological systems at the most fundamental level. Among the various imaging techniques available for biomolecules and their assembled nanostructures, scanning probe microscopy (SPM) provides a powerful and nondestructive imaging option. SPM is unique in visualizing intrinsically disordered biomolecules at the nanometer scale (e.g., glycans). This review highlights recent achievements in studying biomolecules using SPM technique, focusing on DNA bases, amino acids, proteins, and glycans. The atomic-level analysis of biomolecules made possible by SPM allows for a more accurate definition of the local structure-property relationship. High-resolution SPM imaging of single biomolecules offers a new way to study basic processes of life at the molecular level.

引用

页码：511 / 528

页数：18

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