Efomycine U, a new C2-asymmetric elaiophylin derivative from Streptomyces malaysiensis DSM 4137

被引：3

作者：

Xu, Jing ^{[1
,2
]}

Wu, Jingwan ^{[1
]}

Zhou, Dongdong ^{[1
]}

Zhang, Xuexia ^{[1
]}

Leadlay, Peter F. ^{[2
]}

机构：

[1] Hainan Univ, Collaborat Innovat Ctr Ecol Civilizat, Sch Chem Engn & Technol, Haikou, Peoples R China

[2] Univ Cambridge, Dept Biochem, Cambridge, England

来源：

NATURAL PRODUCT RESEARCH | 2024年 / 38卷 / 17期

基金：

中国国家自然科学基金;

关键词：

Streptomyces malaysiensis; efomycine U; structure identification; biological activities; BIOSYNTHETIC GENE-CLUSTER; METABOLITES; IDENTIFICATION;

D O I：

10.1080/14786419.2023.2214839

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Chemical examination of an actinomycete strain Streptomyces malaysiensis DSM 4137 derived from a soil sample derived isolate Streptomyces sp. DSM 3816, yielded a new C-2-asymmetric elaiophylin derivative efomycine U (1) and a known analogue halichoblelide D (2). These structures were unambiguously elucidated on the basis of extensive NMR spectroscopic and mass spectrometric analyses. All compounds isolated were subjected to antimicrobial, cytotoxic and immnosuppressive activities evaluation.

引用

页码：3057 / 3062

页数：6

共 33 条

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