Discovery of a non-canonical function of SYNGAP1 at early stages of human cortical neurogenesis

被引：0
|
作者：
Birtele, Marcella [1 ]
Quadrato, Giorgia [1 ]
机构：
[1] USC, Ely & Edythe Broad CIRM Ctr Regenerat Med & Stem, Los Angeles, CA 90007 USA
来源：
NATURE NEUROSCIENCE | 2023年 / 26卷 / 12期
关键词：
D O I：
10.1038/s41593-023-01486-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We discovered expression of SYNGAP1, which encodes the 'synaptic' protein SYNGAP1, within human cortical progenitors. In an organoid model of SYNGAP1 haploinsufficiency, cortical neurogenesis and neuronal network activity were disrupted. This finding reveals an unknown function for SYNGAP1 at early stages of development, providing a new framework for understanding the pathophysiology of autism spectrum disorder.
引用
收藏
页码：2050 / 2051
页数：2
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