Applications of palladium-catalyzed C-N cross-coupling reactions in pharmaceutical compounds

被引：12

作者：

Emadi, Reza ^{[1
]}

Nekoo, Abbas Bahrami ^{[2
]}

Molaverdi, Fatemeh ^{[3
]}

Khorsandi, Zahra ^{[5
]}

Sheibani, Reza ^{[4
]}

Sadeghi-Aliabadi, Hojjat ^{[5
]}

机构：

[1] Univ Tehran, Inst Biochem & Biophys IBB, Dept Biochem, Tehran, Iran

[2] Nanoalvand Pharmaceut Co, Dept Qual Control, Unit Raw Mat, Simindasht, Alborz, Iran

[3] Univ Tehran, Coll Sci, Sch Chem, Dept Organ Chem, Tehran, Iran

[4] Amirkabir Univ Technol Mahshahr Campus, Univ St, Mahshahr, Khouzestan, Iran

[5] Isfahan Univ Med Sci, Pharmaceut Sci Res Ctr, Sch Pharm & Pharmaceut Sci, Esfahan 8174673461, Iran

来源：

RSC ADVANCES | 2023年 / 13卷 / 27期

关键词：

BIOLOGICAL EVALUATION; KINASE INHIBITORS; BOND FORMATION; ARYL CHLORIDES; NITROGEN-HETEROCYCLES; LEAD OPTIMIZATION; POTENT; DISCOVERY; DESIGN; DERIVATIVES;

D O I：

10.1039/d2ra07412e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

C-N cross-coupling bond formation reactions have become valuable approaches to synthesizing anilines and their derivatives, known as important chemical compounds. Recent developments in this field have focused on versatile catalysts, simple operation methods, and green reaction conditions. This review article presents an overview of C-N cross-coupling reactions in pharmaceutical compound synthesis reports. Selected examples of N-arylation reactions of various nitrogen-based compounds and aryl halides are defined for preparing pharmaceutical molecules.

引用

页码：18715 / 18733

页数：19

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