Total Synthesis of (-)-Enigmazole A by the Macrocyclization/Transannular Pyran Cyclization Strategy

被引：2

作者：

Masuda, Taisei ^{[1
]}

Ohyama, Kyoya ^{[1
]}

Yoshimura, Atsushi ^{[1
]}

Fuwa, Haruhiko ^{[1
]}

机构：

[1] Chuo Univ, Fac Sci & Engn, Dept Appl Chem, Tokyo 1128551, Japan

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 10期

基金：

日本学术振兴会;

关键词：

ENIGMAZOLE; OXIDATION;

D O I：

10.1021/acs.orglett.4c00290

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An 18-step synthesis of (-)-enigmazole A is herein disclosed. The present synthesis is based on a modular assembly of three building blocks of similar complexity, a macrocyclic ring-closing metathesis to forge the 18-membered macrocyclic skeleton, and a desilylative transannular oxa-Michael addition for stereoselective construction of the 2,6-cis-substituted tetrahydropyran ring.

引用

页码：2045 / 2050

页数：6

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