Prognostic accuracy of qSOFA score, SIRS criteria, and EWSs for in-hospital mortality among adult patients presenting with suspected infection to the emergency department (PASSEM) Multicenter prospective external validation cohort study protocol

被引：0

作者：

Algarni, Abdullah M. ^{[1
]}

Alfaifi, Musa S. ^{[2
]}

Al Bshabshe, Ali A. ^{[3
]}

Omair, Othman M. ^{[4
]}

Alsultan, Mohammed A. ^{[5
]}

Alzahrani, Hasan M. ^{[3
]}

Alali, Hadi E. ^{[2
]}

Alsabaani, Abdullah A. ^{[3
]}

Alqarni, Ali M. ^{[6
]}

Alghanem, Salah A. ^{[7
]}

Al Mufareh, Bandar S. ^{[8
]}

Almemari, Ayesha M. ^{[9
]}

Sindi, Abdulrahman A. ^{[10
]}

Ozturan, Ibrahim U. ^{[11
]}

Alhadhira, Abdullah A. ^{[12
]}

Shujaa, Asaad S. ^{[12
]}

Alotaibi, Abdullah H. ^{[13
]}

Awladthani, Moosa M. ^{[14
]}

Alsaad, Ahmed A. ^{[15
]}

Almarshed, Abdullah A. ^{[16
]}

Alqahtani, AlHanouv M. ^{[17
]}

Harris, Tim R. ^{[18
]}

Alyahya, Bader A. ^{[19
]}

Assiri, Saad A. ^{[20
]}

Abuzeyad, Feras H. ^{[21
]}

Kazim, Sara N. ^{[22
]}

Al-Fares, Abdulrahman A. ^{[23
]}

Almazroua, Faisal Y. ^{[24
]}

Marzook, Naif T. ^{[25
]}

Basri, Abdullah A. ^{[7
]}

Elsafti, Abdallah M. ^{[18
]}

Alalshaikh, Abdulaziz S. ^{[19
]}

Oezturan, Cansu A. ^{[26
]}

Alawad, Yousef I. ^{[27
]}

Alomari, Awad ^{[28
]}

Alkhateeb, Malek A. ^{[20
]}

Farooq, Moonis M. ^{[21
]}

Almutairi, Latifa Ali ^{[29
]}

Alasfour, Muneera M. ^{[29
]}

Al Haber, Mohammad I. ^{[9
]}

Umar, Umma-Kulthum A. ^{[9
]}

Bokhary, Nidal H. ^{[10
]}

Alqahtani, Saeed F. ^{[4
]}

Almutairi, Abdulrhman ^{[24
]}

Alyahya, Hisham F. ^{[24
]}

Alzahrani, Wejdan S. ^{[25
]}

Alsalmi, Fawziah ^{[25
]}

Omair, Abdulmajeed M. ^{[3
]}

Alasmari, Faysal M. ^{[3
]}

Alfifi, Sultan Y. ^{[3
]}

机构：

[1] Aseer Cent Hosp, Family Med Dept, Abha, Saudi Arabia

[2] Armed Forces Hosp Southern Reg, Emergency Med Dept, Khamis Mushait, Saudi Arabia

[3] King Khalid Univ, Coll Med, Abha, Saudi Arabia

[4] Aseer Cent Hosp, Emergency Med Dept, Abha, Saudi Arabia

[5] Saudi Commiss Hlth Special, Riyadh, Saudi Arabia

[6] Prince Mashary Bin Saud Hosp, Radiol Dept, Belgraishi, Saudi Arabia

[7] Bahrain Def Force Hosp, Emergency Med Dept, Al Riffa, Bahrain

[8] Royal Commiss Hosp Jubail, Emergency Med Dept, Jubail Ind City, Saudi Arabia

[9] Shaikh Shakhbout Med City, Emergency Med Dept, Abu Dhabi, U Arab Emirates

[10] King Abdulaziz Univ, Coll Med, Jeddah, Saudi Arabia

[11] Kocaeli Univ, Fac Med, Emergency Med Dept, Kocaeli, Turkiye

[12] Johns Hopkins Aramco Healthcare, Emergency Med Dept, Dhahran, Saudi Arabia

[13] King Abdullah Univ Hosp, Emergency Med Dept, Riyadh, Saudi Arabia

[14] Armed Forces Hosp Oman, Crit Care Dept, Muscat, Oman

[15] King Fahad Specialist Hosp, Emergency Med Dept, Dammam, Saudi Arabia

[16] King Fahad Med City, Emergency Med Dept, Riyadh, Saudi Arabia

[17] North Med Tower Hosp, Emergency Med Dept, Ar Ar, Saudi Arabia

[18] Hamad Med Corp, Emergency Med Dept, Doha, Qatar

[19] King Saud Univ, Coll Med, Riyadh, Saudi Arabia

[20] Sulaiman Al Habib Med Grp, Emergency Med Dept, Riyadh, Saudi Arabia

[21] King Hamad Univ Hosp, Emergency Med Dept, Muharraq, Bahrain

[22] Rashid Hosp, Emergency Med Dept, Dubai, U Arab Emirates

[23] Al Amiri Hosp, Crit Care Dept, Kuwait, Kuwait

[24] King Saud Med City, Emergency Med Dept, Riyadh, Saudi Arabia

[25] King Fahad Armed Forces Hosp, Emergency Med Dept, Jeddah, Saudi Arabia

[26] Golcuk Necati Celik State Hosp, Emergency Med Dept, Kocaeli, Turkiye

[27] King Fahad Med City, Emergency Med Adm, Riyadh, Saudi Arabia

[28] Sulaiman Al Habib Med Grp, Crit Care Dept, Riyadh, Saudi Arabia

[29] Al Amiri Hosp, Emergency Med Dept, Kuwait, Kuwait

[30] McMaster Univ, Hlth Res Methods Evidence & Impact, Hamilton, ON, Canada

来源：

PLOS ONE | 2024年 / 19卷 / 01期

关键词：

INTERNATIONAL CONSENSUS DEFINITIONS; GOAL-DIRECTED RESUSCITATION; SEPTIC SHOCK; CLINICAL-CRITERIA; SEVERE SEPSIS; MODEL;

D O I：

10.1371/journal.pone.0281208

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background Early identification of a patient with infection who may develop sepsis is of utmost importance. Unfortunately, this remains elusive because no single clinical measure or test can reflect complex pathophysiological changes in patients with sepsis. However, multiple clinical and laboratory parameters indicate impending sepsis and organ dysfunction. Screening tools using these parameters can help identify the condition, such as SIRS, quick SOFA (qSOFA), National Early Warning Score (NEWS), or Modified Early Warning Score (MEWS). We aim to externally validate qSOFA, SIRS, and NEWS/NEWS2/MEWS for in-hospital mortality among adult patients with suspected infection who presenting to the emergency department. Methods and analysis PASSEM study is an international prospective external validation cohort study. For 9 months, each participating center will recruit consecutive adult patients who visited the emergency departments with suspected infection and are planned for hospitalization. We will collect patients' demographics, vital signs measured in the triage, initial white blood cell count, and variables required to calculate Charlson Comorbidities Index; and follow patients for 90 days since their inclusion in the study. The primary outcome will be 30-days in-hospital mortality. The secondary outcome will be intensive care unit (ICU) admission, prolonged stay in the ICU (i.e., >= 72 hours), and 30- as well as 90-days all-cause mortality. The study started in December 2021 and planned to enroll 2851 patients to reach 200 in-hospital death. The sample size is adaptive and will be adjusted based on prespecified consecutive interim analyses. Discussion PASSEM study will be the first international multicenter prospective cohort study that designated to externally validate qSOFA score, SIRS criteria, and EWSs for in-hospital mortality among adult patients with suspected infection presenting to the ED in the Middle East region.

引用

页数：14

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