Several theories describe the increasing enlargement of the human brain because of environmental changes or dietary alterations. The environmental changes led to a change in diet quality (micronutrient density) because of changes in food foraging, which ensured that a growing brain was adequately supplied with energy and essential micronutrients for growth. The hippocampus is a direct link between nutrition and the environment, which is necessary for adapting to a changing climate. The adaptation then improves foraging success and enables better food quality and thus favors the development of the hippocampus, which in turn influences the development of other brain regions.The extraordinary ability of our ancestors for persistent running not only favored hunting but also had direct effects on hormones that support brain development. The connection between physical exercise, nutrition, and plasticity of the hippocampus and the resulting adaptation to changing environmental conditions is essential for triggering or stimulating brain development. As the variability selection hypothesis proposes, fluctuations in environmental conditions need a short adaptive answer, which may become genetically fixed and selected. The presented hypothesis allows a meaningful combination of the different theories of brain development (pulse climate, variability selection, amplifier lakes) and nutrition theories (aquatic, cooking, energy).The assumption that the hippocampus, as a "central sensory organ", detects new events and enables an adaptive response is not an isolated assumption for the hippocampus since other brain regions can also react similarly with synaptic plasticity. Through adult hippocampal neurogenesis (AHN), which is unique only in the hippocampus and synaptic plasticity, there is the possibility of detection and (neurological) storage of previously unknown events and linking them to other cortical areas, which may increase cortical volume.
机构:
Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell R, San Francisco, CA 94143 USA
Univ Calif San Francisco, Biomed Sci Grad Program, San Francisco, CA USA
Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USAUniv Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell R, San Francisco, CA 94143 USA
Fair, Tyler
Pollen, Alex A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell R, San Francisco, CA 94143 USA
Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USAUniv Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell R, San Francisco, CA 94143 USA
机构:
Yale Sch Med, Dept Neurosci, New Haven, CT 06510 USA
Yale Child Study Ctr, New Haven, CT 06510 USAYale Sch Med, Dept Neurosci, New Haven, CT 06510 USA
Pattabiraman, Kartik
Muchnik, Sydney Keaton
论文数: 0引用数: 0
h-index: 0
机构:
Yale Sch Med, Dept Neurosci, New Haven, CT 06510 USA
Yale Sch Med, Dept Genet, New Haven, CT 06510 USAYale Sch Med, Dept Neurosci, New Haven, CT 06510 USA
Muchnik, Sydney Keaton
Sestan, Nenad
论文数: 0引用数: 0
h-index: 0
机构:
Yale Sch Med, Dept Neurosci, New Haven, CT 06510 USA
Yale Child Study Ctr, New Haven, CT 06510 USA
Yale Sch Med, Dept Genet, New Haven, CT 06510 USA
Yale Sch Med, Dept Psychiat, New Haven, CT 06510 USA
Yale Sch Med, Dept Comparat Med, Kavli Inst Neurosci, Program Cellular Neurosci Neurodegenerat & Repair, New Haven, CT 06510 USAYale Sch Med, Dept Neurosci, New Haven, CT 06510 USA
机构:
Columbia Univ, Dept Anthropol, New York, NY 10027 USAColumbia Univ, Dept Anthropol, New York, NY 10027 USA
Holloway, Ralph L.
Broadfield, Douglas C.
论文数: 0引用数: 0
h-index: 0
机构:
Florida Atlantic Univ, Dept Anthropol, Boca Raton, FL 33431 USAColumbia Univ, Dept Anthropol, New York, NY 10027 USA
Broadfield, Douglas C.
Carlson, Kristian
论文数: 0引用数: 0
h-index: 0
机构:
Univ Witwatersrand, Inst Human Evolut, ZA-2050 Johannesburg, South Africa
Indiana Univ, Dept Anthropol, Bloomington, IN 47405 USAColumbia Univ, Dept Anthropol, New York, NY 10027 USA
机构:
Univ Maastricht, NUTRIM, Nutr & Toxicol Res Inst, Dept Human Biol, NL-6200 MD Maastricht, NetherlandsUniv Maastricht, NUTRIM, Nutr & Toxicol Res Inst, Dept Human Biol, NL-6200 MD Maastricht, Netherlands
Saris, Wim H. M.
Heymsfield, Steven B.
论文数: 0引用数: 0
h-index: 0
机构:
Merck & Co Inc, Rahway, NJ 07065 USAUniv Maastricht, NUTRIM, Nutr & Toxicol Res Inst, Dept Human Biol, NL-6200 MD Maastricht, Netherlands
Heymsfield, Steven B.
Evans, William J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arkansas Med Sci, Donald W Reynolds Inst Aging, Little Rock, AR 72205 USAUniv Maastricht, NUTRIM, Nutr & Toxicol Res Inst, Dept Human Biol, NL-6200 MD Maastricht, Netherlands
Evans, William J.
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE,
2008,
11
(06):
: 683
-
685