Rapid Progression of Focal Segmental Glomerulosclerosis in Patients with High-Risk APOL1 Genotypes

被引：11

作者：

Kallash, Mahmoud ^{[1
]}

Wang, Yujie ^{[2
]}

Smith, Abigail ^{[3
]}

Trachtman, Howard ^{[4
]}

Gbadegesin, Rasheed ^{[5
]}

Nester, Carla ^{[6
]}

Canetta, Pietro ^{[7
]}

Wang, Chen ^{[7
]}

Hunley, Tracy E. ^{[8
]}

Sperati, C. John ^{[9
]}

Selewski, David ^{[10
]}

Ayoub, Isabelle ^{[11
]}

Srivastava, Tarak ^{[12
]}

Mottl, Amy K. ^{[13
]}

Kopp, Jeffrey ^{[14
]}

Gillespie, Brenda ^{[15
]}

Robinson, Bruce ^{[3
]}

Chen, Dhruti ^{[13
]}

Steinke, Julia ^{[16
]}

Twombley, Katherine ^{[10
]}

Reidy, Kimberly ^{[17
]}

Mucha, Krzysztof ^{[18
,19
]}

Greenbaum, Larry A. ^{[20
,21
]}

Blazius, Brooke ^{[4
]}

Helmuth, Margaret ^{[3
]}

Yonatan, Peleg ^{[7
]}

Parekh, Rulan S. ^{[22
,23
,24
]}

Hogan, Susan ^{[13
]}

Royal, Virginie ^{[25
]}

D'Agati, Vivette ^{[26
]}

Chishti, Aftab ^{[27
]}

Falk, Ronald ^{[13
]}

Gharavi, Ali ^{[7
]}

Holzman, Lawrence ^{[28
]}

Klein, Jon ^{[29
]}

Smoyer, William ^{[1
]}

Kretzler, Matthias ^{[30
]}

Gipson, Debbie ^{[4
]}

Kidd, Jason M. ^{[31
]}

机构：

[1] Nationwide Childrens Hosp, Div Pediat Nephrol, Columbus, OH USA

[2] Univ Michigan, Ann Arbor, MI USA

[3] Arbor Res Collaborat Hlth, Ann Arbor, MI USA

[4] Univ Michigan, Dept Pediat, Div Nephrol, Ann Arbor, MI USA

[5] Duke Childrens Hosp & Hlth Ctr, Dept Pediat Nephrol, Durham, NC USA

[6] Univ Iowa, Stead Family Dept Pediat, Div Pediat Nephrol Dialysis & Transplantat, Iowa, IA USA

[7] Columbia Univ, Coll Phys & Surg, Dept Med, Div Nephrol, New York, NY USA

[8] Vanderbilt Univ, Med Ctr, Div Pediat Nephrol, Nashville, TN USA

[9] Johns Hopkins Univ, Sch Med, Div Nephrol, Baltimore, MD USA

[10] Med Univ South Carolina, Dept Pediat Nephrol, Charleston, SC USA

[11] Ohio State Univ, Wexner Med Ctr, Dept Med, Div Nephrol, Columbus, OH USA

[12] Univ Missouri Kansas City, Sch Med, Childrens Mercy Hosp, Kansas City, MO USA

[13] Univ North Carolina, Kidney Ctr, Dept Med, Div Nephrol & Hypertens, Chapel Hill, NC USA

[14] NIDDKD, NIH, Kidney Dis Branch, Kidney Dis Sect, Bethesda, MD USA

[15] Univ Michigan, Sch Publ Hlth, Dept Biostat, Ann Arbor, MI USA

[16] Helen DeVos Childrens Hosp, Div Med Subspecialties, Sect Pediat Nephrol, Grand Rapids, MI USA

[17] Albert Einstein Coll Med, Childrens Hosp Montefiore, Dept Pediat Nephrol, Bronx, NY USA

[18] Med Univ Warsaw, Dept Immunol Transplantol & Internal Dis, Warsaw, Poland

[19] Polish Acad Sci, Inst Biochem & Biophys, Warsaw, Poland

[20] Emory Univ, Dept Pediat, Div Pediat Nephrol, Atlanta, GA USA

[21] Childrens Healthcare Atlanta, Atlanta, GA USA

[22] Hosp Sick Children, Div Pediat Nephrol, Toronto, ON, Canada

[23] Hosp Sick Children, Res Inst, Child Hlth Evaluat Sci, Toronto, ON, Canada

[24] Univ Hlth Network, Dept Med, Div Nephrol, Toronto, ON, Canada

[25] Univ Montreal, Hop Maisonneuve Rosemont, Div Pathol, Montreal, PQ, Canada

[26] Columbia Univ, Med Ctr, Dept Pathol, New York, NY USA

[27] Univ Kentucky, Div Nephrol Hypertens & Renal Transplantat, Lexington, KY USA

[28] Univ Penn, Sch Med, Dept Internal Med, Philadelphia, PA USA

[29] Univ Louisville, Sch Med, Dept Med Renal, Louisville, KY USA

[30] Univ Michigan, Dept Internal Med, Div Nephrol, Ann Arbor, MI USA

[31] Virginia Commonwealth Univ, Div Nephrol, Richmond, VA USA

来源：

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2023年 / 18卷 / 03期

关键词：

focal segmental glomerulosclerosis; proteinuria; nephrotic syndrome; glomerular disease; KIDNEY-FUNCTION DECLINE; VARIANTS ASSOCIATE; NEPHROPATHY; CHILDREN; DISEASE; ADULTS;

D O I：

10.2215/CJN.0000000000000069

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background FSGS is a heterogeneous diagnosis with a guarded prognosis. Polymorphisms in the apolipoprotein L1 (APOL1) gene are associated with developing FSGS and faster progression to kidney failure in affected patients. Better understanding the natural history of patients with FSGS and APOL1 risk alleles is essential to improve patient care and support the design and interpretation of interventional studies. The objective of this study was to evaluate the quantitative association between APOL1 and kidney disease progression and the interaction with other clinical and laboratory factors. Methods CureGN cohort study participants with biopsy diagnosis of FSGS, regardless of self-identified race, were included. The exposure of interest was two APOL1 risk alleles (high risk) versus zero to one risk alleles (low risk). The primary outcome was eGFR slope categorized as rapid progressor (eGFR slope #-5 ml/min per year), intermediate progressor (slope between 0 and -5), or nonprogressor (slope $0). Multivariable ordinal logistic and linear regressions were used for adjusted analyses. Missing data were addressed using multiple imputation. Results Of 650 participants, 476 (73%) had genetic testing, among whom 87 (18%) were high risk. High-risk participants were more likely to have lower median eGFR (62 [interquartile range, 36-81] versus low-risk participants 76 ml/min per 1.73 m(2) [interquartile range, 44-106]; P < 0.01). In adjusted analysis, the odds of more rapid progression of eGFR was 2.75 times higher (95% confidence interval, 1.67 to 4.53; P < 0.001) in the high-risk versus low-risk groups. Conclusions In patients with FSGS, high-risk APOL1 genotype is the predominant factor associated with more rapid loss of kidney function.

引用

页码：344 / 355

页数：12

共 50 条

[41] Donor APOL1 high-risk genotypes are associated with increased risk and inferior prognosis of de novo collapsing glomerulopathy in renal allografts
Santoriello, Dominick
Husain, Syed A.
De Serres, Sacha A.
Bomback, Andrew S.
Crew, Russell J.
Vasilescu, Elena-Rodica
Serban, Geo
Campenot, Eric S.
Kiryluk, Krzysztof
Mohan, Sumit
Hawkins, Gregory A.
Hicks, Pamela J.
Cohen, David J.
Radhakrishnan, Jai
Stokes, Michael B.
Markowitz, Glen S.
Freedman, Barry I.
D'Agati, Vivette D.
Batal, Ibrahim
KIDNEY INTERNATIONAL, 2018, 94 (06) : 1189 - 1198
[42] APOL1 High-Risk Genotypes and Kidney Disease Risk in Middle-Aged Black Adults: More Questions Than Answers
Gutierrez, Orlando M.
KIDNEY MEDICINE, 2024, 6 (06)
[43] Predictors of Progression to Kidney Failure in Patients With Focal Segmental Glomerulosclerosis
Tuttle, Katherine R.
Daratha, Kenn B.
Jones, Cami R.
Kornowske, Lindsey M.
Alicic, Radica Z.
Bunke, Martin C.
Thakker, Kamlesh M.
Amari, Diana T.
Pinto, Lionel
Wang, Kaijun
Norris, Keith C.
Nicholas, Susanne B.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2022, 33 (11): : 504 - 504
[44] Human iPSC-Derived Podocytes to Study APOL1 High-Risk Variants
Haines, Lauren
Tran, Uyen
O'Toole, John F.
Sedor, John R.
Wessely, Oliver
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2022, 33 (11): : 806 - 806
[45] Multi-Ethnic Polygenic Risk Modifies the Association Between APOL1 High Risk Genotypes and CKD
Thi Ha My Vy
Gulamali, Faris F.
Nadkarni, Girish N.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2022, 33 (11): : 409 - 410
[46] Idiopathic collapsing glomerulopathy is associated with APOL1 high-risk genotypes or Mendelian variants in most affected individuals in a highly admixed population
Neves, Precil
Watanabe, Andreia
Watanabe, Elieser
Narcizo, Amanda
Nunes, Kelly
Lerario, Antonio
Ferreira, Frederico
Cavalcante, Livia
Wongboonsin, Janewit
Malheiros, Denise
Jorge, Lecticia
Sampson, Matthew
Noronha, Irene
Onuchic, Luiz
KIDNEY INTERNATIONAL, 2024, 105 (03) : 593 - 607
[47] Renal and Cardiovascular Morbidities Associated with APOL1 Status among African-American and Non-African-American Children with Focal Segmental Glomerulosclerosis
Woroniecki, Robert P.
Ng, Derek K.
Limou, Sophie
Winkler, Cheryl A.
Reidy, Kimberly J.
Mitsnefes, Mark
Sampson, Matthew G.
Wong, Craig S.
Warady, Bradley A.
Furth, Susan L.
Kopp, Jeffrey B.
Kaskel, Frederick J.
FRONTIERS IN PEDIATRICS, 2016, 4
[48] APOL1 Risk Variants, Race, and Progression of Chronic Kidney Disease
Parsa, Afshin
Kao, W. H. Linda
Xie, Dawei
Astor, Brad C.
Li, Man
Hsu, Chi-yuan
Feldman, Harold I.
Parekh, Rulan S.
Kusek, John W.
Greene, Tom H.
Fink, Jeffrey C.
Anderson, Amanda H.
Choi, Michael J.
Wright, Jackson T., Jr.
Lash, James P.
Freedman, Barry I.
Ojo, Akinlolu
Winkler, Cheryl A.
Raj, Dominic S.
Kopp, Jeffrey B.
He, Jiang
Jensvold, Nancy G.
Tao, Kaixiang
Lipkowitz, Michael S.
Appel, Lawrence J.
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (23): : 2183 - 2196
[49] Genome-Wide Epistatic Interaction between DEF1B and APOL1 High-Risk Genotypes for Chronic Kidney Disease
Vy, Ha My T.
Lin, Bridget M.
Gulamali, Faris F.
Kooperberg, Charles
Graff, Mariaelisa
Wong, Jenny
Campbell, Kirk N.
Matise, Tara C.
Coresh, Josef
Thomas, Fridtjof
Reiner, Alexander P.
Nassir, Rami
Schnatz, Peter F.
Johns, Tanya
Buyske, Steven
Haiman, Christopher
Cooper, Richard
Loos, Ruth J. F.
Horowitz, Carol R.
Gutierrez, Orlando M.
Do, Ron
Franceschini, Nora
Nadkarni, Girish N.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2022, 17 (10): : 1522 - 1525
[50] Schistosoma mansoni infection as a trigger to collapsing glomerulopathy in a patient with high-risk APOL1 genotype
Neves, Precil D.
Bridi, Ramaiane A.
Ramalho, Janaina A.
Jorge, Lecticia B.
Watanabe, Elieser H.
Watanabe, Andreia
Yu, Luis
Woronik, Viktoria
Pinheiro, Rafaela B.
Testagrossa, Leonardo A.
Cavalcante, Livia B.
Malheiros, Denise M.
Dias, Cristiane B.
Onuchic, Luiz F.
PLOS NEGLECTED TROPICAL DISEASES, 2020, 14 (10): : 1 - 7

← 1 2 3 4 5 →