Palladium-Catalyzed Cyclopropanation of Aryl/Heteroaryl Fluoro-sulfonates

被引：2
|
作者：
Guan, Chenfei [1 ]
Qi, Huijie [1 ]
Han, Linjun [1 ]
Liu, Miaoyu [1 ]
Wang, Jing [2 ]
Zhang, Guofu [1 ]
Ding, Chengrong [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Peoples R China
[2] Lianhe Chem Technol Co Ltd, Huangyan 318020, Taizhou, Peoples R China
来源：
CHEMISTRYSELECT | 2023年 / 8卷 / 10期
关键词：
Cyclopropanation; Palladium-catalyzed; Aryl; heteroaryl fluorosulfate; One-pot reaction; Late-stage functionalization; ALCOHOLS;
D O I：
10.1002/slct.202300420
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The cyclopropane group is widely present as an important motif in pharmaceuticals and natural products. Herein, we report a cyclopropanation strategy by inexpensive and readily available aryl/heteroaryl fluorosulfonates. The strategy displays wide functional group compatibility and furnishes the corresponding cyclopropane products in excellent yields. The power of this new platform is showcased through one-pot and gram-scale experiments. This is reinforced by its application in late-stage functionalization.
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页数：4
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