An association study of HLA with levofloxacin-induced severe cutaneous adverse drug reactions in Han Chinese

被引：2
|
作者：
Jiang, Menglin [1 ,2 ]
Yang, Jin [3 ,4 ]
Yang, Linlin [5 ]
Wang, Lina [5 ]
Wang, Ting [1 ,2 ]
Han, Shengna [5 ]
Cheng, Ye [1 ,2 ]
Chen, Zihua [3 ,4 ]
Su, Yu [1 ,2 ]
Zhang, Lirong [5 ]
Yang, Fanping [3 ,4 ]
Chen, Sheng-an [3 ,4 ]
Zhang, Jin [1 ,2 ]
Xiong, Hao [3 ,4 ]
Wang, Lanting [3 ,4 ]
Zhang, Zhen [3 ,4 ]
Ma, Li [3 ,4 ]
Luo, Xiaoqun [3 ,4 ]
Xing, Qinghe [1 ,2 ]
机构：
[1] Fudan Univ, Childrens Hosp, Shanghai 200032, Peoples R China
[2] Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China
[3] Fudan Univ, Huashan Hosp, Dept Allergy & Immunol, Shanghai 200040, Peoples R China
[4] Fudan Univ, Huashan Hosp, Dept Dermatol, Shanghai 200040, Peoples R China
[5] Zhengzhou Univ, Sch Basic Med Sci, Dept Pharmacol, Zhengzhou 450001, Peoples R China
来源：
ISCIENCE | 2023年 / 26卷 / 08期
基金：
中国国家自然科学基金;
关键词：
TOXIC EPIDERMAL NECROLYSIS; STEVENS-JOHNSON SYNDROME; HYPERSENSITIVITY REACTIONS; SYSTEMIC SYMPTOMS; RISK; HLA-B-ASTERISK-1301; EOSINOPHILIA; ALLOPURINOL; PEPTIDES; ALLELE;
D O I：
10.1016/j.isci.2023.107391
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Levofloxacin-induced severe cutaneous adverse drug reactions (LEV-SCARs) remain unexplored. An association study of human leukocyte antigen (HLA) alleles with LEV-SCARs among 12 patients, 806 healthy subjects, and 100 levofloxacin-tolerant individuals was performed. The carrier frequencies of HLA-B*13:01 (odds ratio [OR]: 4.50; 95% confidence interval [CI]: 1.15-17.65; p = 0.043), HLA-B*13:02 (OR: 6.14; 95% CI: 1.73-21.76; p = 0.0072), and serotype B13 (OR: 17.73; 95% CI: 3.61-86.95; p = 4.85 x 10(-5)) in patients with LEV-SCARs were significantly higher than those of levofloxacin-tolerant individuals. Molecular docking analysis suggested that levofloxacin formed more stable binding models with HLA-B*13:01 and HLA-B*13:02 than with non-risk HLA-B*46:01. Mass spectrometry revealed that nonapeptides bound to HLA-B*13:02 shifted at several positions after exposure to levofloxacin. Prospective screening for serotype B13 (sensitivity: 83%, specificity: 78%) and alternative drug treatment for carriers may significantly decrease the incidence of LEV-SCARs.
引用
收藏
页数：14
相关论文
共 50 条
  • [21] Severe cutaneous adverse drug reactions
    Chung, Wen-Hung
    Wang, Chuang-Wei
    Dao, Ro-Lan
    JOURNAL OF DERMATOLOGY, 2016, 43 (07): : 758 - 766
  • [22] Severe Cutaneous Adverse Drug Reactions
    Schroeder, J.
    DRUG SAFETY, 2013, 36 (09) : 942 - 942
  • [23] severe cutaneous adverse drug reactions induced by allopurinol preventable?
    Ranchon, F.
    Debarbieux, S.
    Bensaid, B.
    Bernard, N.
    Nicolas, J. F.
    Descotes, J.
    Vial, T.
    FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2009, 23 : 103 - 103
  • [24] HLA-B*58:01 allele is associated with augmented risk for both mild and severe cutaneous adverse reactions induced by allopurinol in Han Chinese
    Cao, Zhi Hao
    Wei, Zhi-yun
    Zhu, Qin-yuan
    Zhang, Jun-yu
    Yang, Lun
    Qin, Sheng-ying
    Shao, Li-yan
    Zhang, Yi-ting
    Xuan, Jie-kun
    Li, Qiao-li
    Xu, Jin-hua
    Xu, Feng
    Ma, Li
    Huang, Hui-yuan
    Xing, Qing-he
    Luo, Xiao-qun
    PHARMACOGENOMICS, 2012, 13 (10) : 1193 - 1201
  • [25] ASSOCIATION BETWEEN HLA-B*1502 ALLELE AND CUTANEOUS REACTIONS INDUCED BY CARBAMAZEPINE OR LAMOTRIGINE IN HAN CHINESE
    Liao, Wei-Ping
    Shi, Y. W.
    Cheng, S. H.
    Ng, M. H.
    Kwan, P.
    EPILEPSIA, 2009, 50 : 252 - 253
  • [26] HLA genetic polymorphism and severe cutaneous adverse drug reactions in a Thai population
    Tassaneeyakul, Wichittra
    DRUG METABOLISM REVIEWS, 2011, 43 : 17 - 17
  • [27] HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in Vietnamese
    Dinh Van Nguyen
    Hieu Chi Chu
    Doan Van Nguyen
    Minh Hong Phan
    Craig, Timothy
    Baumgart, Karl
    van Nunen, Sheryl
    ASIA PACIFIC ALLERGY, 2015, 5 (02) : 68 - 77
  • [28] Association between HLA-B*1502 allele and carbamazepine-induced severe cutaneous adverse reactions in Han people of southern China mainland
    Wang, Qian
    Zhou, Jue-qian
    Zhou, Lie-min
    Chen, Zi-yi
    Fang, Zi-yan
    Chen, Shu-da
    Yang, Li-bai
    Cai, Xiao-dong
    Dai, Qi-lin
    Hong, Hua
    Wang, Hong-xuan
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2011, 20 (06): : 446 - 448
  • [29] SNP-based HLA allele tagging, imputation and association with antiepileptic drug-induced cutaneous reactions in Hong Kong Han Chinese
    H Gui
    M Kwok
    L Baum
    P C Sham
    P Kwan
    S S Cherny
    The Pharmacogenomics Journal, 2018, 18 : 340 - 346
  • [30] SNP-based HLA allele tagging, imputation and association with antiepileptic drug-induced cutaneous reactions in Hong Kong Han Chinese
    Gui, H.
    Kwok, M.
    Baum, L.
    Sham, P. C.
    Kwan, P.
    Cherny, S. S.
    PHARMACOGENOMICS JOURNAL, 2018, 18 (02): : 340 - 346
12345