New Advances in Metabolic Syndrome, from Prevention to Treatment: The Role of Diet and Food

被引：73

作者：

Ambroselli, Donatella ^{[1
]}

Masciulli, Fabrizio ^{[1
]}

Romano, Enrico ^{[1
]}

Catanzaro, Giuseppina ^{[2
]}

Besharat, Zein Mersini ^{[2
]}

Massari, Maria Chiara ^{[2
]}

Ferretti, Elisabetta ^{[2
]}

Migliaccio, Silvia ^{[3
]}

Izzo, Luana ^{[4
]}

Ritieni, Alberto ^{[4
,5
]}

Grosso, Michela ^{[6
]}

Formichi, Caterina ^{[7
]}

Dotta, Francesco ^{[7
]}

Frigerio, Francesco ^{[2
]}

Barbiera, Eleonora ^{[2
]}

Giusti, Anna Maria ^{[2
]}

Ingallina, Cinzia ^{[1
]}

Mannina, Luisa ^{[1
]}

机构：

[1] Sapienza Univ Rome, Dept Chem & Technol Drugs, Lab Food Chem, I-00185 Rome, Italy

[2] Sapienza Univ Rome, Dept Expt Med, I-00161 Rome, Italy

[3] Univ Foro Italico, Dept Movement Human & Hlth Sci, Hlth Sci Sect, I-00135 Rome, Italy

[4] Univ Naples Federico II, Dept Pharm, I-80131 Naples, Italy

[5] Univ Naples Federico II, UNESCO, Hlth Educ & Sustainable Dev, I-80131 Naples, Italy

[6] Univ Naples Federico II, Dept Mol Med & Med Biotechnol, I-80131 Naples, Italy

[7] Univ Siena, Dept Med, Diabet Unit, Surg & Neurosci, I-53100 Siena, Italy

来源：

NUTRIENTS | 2023年 / 15卷 / 03期

关键词：

metabolic syndrome; food; food components; diet; metabolomics; biomarkers; POLYUNSATURATED FATTY-ACID; REFINED-GRAIN CONSUMPTION; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; WEIGHT-LOSS; CHLOROGENIC ACID; FISH CONSUMPTION; OXIDATIVE STRESS; BLOOD-PRESSURE; RISK-FACTORS;

D O I：

10.3390/nu15030640

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The definition of metabolic syndrome (MetS) has undergone several changes over the years due to the difficulty in establishing universal criteria for it. Underlying the disorders related to MetS is almost invariably a pro-inflammatory state related to altered glucose metabolism, which could lead to elevated cardiovascular risk. Indeed, the complications closely related to MetS are cardiovascular diseases (CVDs) and type 2 diabetes (T2D). It has been observed that the predisposition to metabolic syndrome is modulated by complex interactions between human microbiota, genetic factors, and diet. This review provides a summary of the last decade of literature related to three principal aspects of MetS: (i) the syndrome's definition and classification, pathophysiology, and treatment approaches; (ii) prediction and diagnosis underlying the biomarkers identified by means of advanced methodologies (NMR, LC/GC-MS, and LC, LC-MS); and (iii) the role of foods and food components in prevention and/or treatment of MetS, demonstrating a possible role of specific foods intake in the development of MetS.

引用

页数：38

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