Abietane diterpenoids with anti-inflammatory activities from Callicarpa bodinieri

被引：4

作者：

Sun, Yue ^{[1
]}

Yang, Hong-Ying ^{[1
]}

Huang, Pei-Zhi ^{[1
]}

Zhang, Lan-Jun ^{[1
]}

Feng, Wei-Jiao ^{[1
]}

Li, Ya ^{[1
]}

Gao, Kun ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

PHYTOCHEMISTRY | 2023年 / 214卷

基金：

中国国家自然科学基金;

关键词：

Callicarpa bodinieri; Lamiaceae; Abietane-type diterpenoids; Anti-inflammatory activities; SESQUITERPENOIDS;

D O I：

10.1016/j.phytochem.2023.113825

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nine undescribed abietane diterpenoids (1-9) and eleven known abietane analogs (10-20) were isolated from Callicarpa bodinieri. Their structures were characterized by interpreting spectroscopic data, X-ray crystallog-raphy, and ECD analysis. The anti-inflammatory activities of these compounds were tested by evaluation of their inhibitory effect on NO production by lipopolysaccharide in RAW 264.7 macrophages, and compounds 3 and 8 exhibited potent anti-inflammatory activities with IC50 values of 36.35 & PLUSMN; 1.12 and 37.21 & PLUSMN; 0.92 & mu;M. The western blotting studies demonstrated that compound 3 inhibited the expression of nitric oxide synthase and p65 that involved in the NF-& kappa;B pathway.

引用

页数：9

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