Role of Siglecs in viral infections: A double-edged sword interaction

被引：11

作者：

Raich-Regue, Dalia ^{[1
]}

Resa-Infante, Patricia ^{[1
,2
]}

Gallemi, Marcal ^{[1
]}

Laguia, Fernando ^{[1
]}

Muniz-Trabudua, Xabier ^{[1
]}

Munoz-Basagoiti, Jordana ^{[1
]}

Perez-Zsolt, Daniel ^{[1
]}

Chojnacki, Jakub ^{[1
,3
]}

Benet, Susana ^{[4
]}

Clotet, Bonaventura ^{[1
,2
,3
,4
,5
]}

Martinez-Picado, Javier ^{[1
,2
,3
,5
,6
]}

Izquierdo-Useros, Nuria ^{[1
,3
,5
]}

机构：

[1] Hosp Germans Trias i Pujol, IrsiCaixa AIDS Res Inst, Badalona 08916, Spain

[2] Univ Vic, Cent Univ Catalonia UV UCC, Vic 08500, Spain

[3] Germans Trias i Pujol Res Inst IGTP, Can Ruti Campus, Badalona 08916, Spain

[4] Hosp Germans Trias i Pujol, Infect Dis Dept, Fundacio lluita SIDA, Badalona 08916, Spain

[5] Consorcio Ctr Invest Biome Red Enfermedades Infecc, Inst Salud Carlos III, Madrid 28029, Spain

[6] Catalan Inst Res, Adv Studies ICREA, Barcelona 08010, Spain

来源：

MOLECULAR ASPECTS OF MEDICINE | 2023年 / 90卷

关键词：

Siglecs; HIV-1; Ebola virus; SARS-CoV-2; Antiviral; ACID-BINDING-RECEPTOR; SUBCAPSULAR SINUS MACROPHAGES; KILLER-CELL SUBSET; DENDRITIC CELLS; INHIBITORY RECEPTOR; MOLECULAR-CLONING; TRANS-INFECTION; CD33-RELATED SIGLECS; HEMATOPOIETIC-CELLS; HIV-1; INFECTION;

D O I：

10.1016/j.mam.2022.101113

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sialic-acid-binding immunoglobulin-like lectins are cell surface immune receptors known as Siglecs that play a paramount role as modulators of immunity. In recent years, research has underscored how the underlaying biology of this family of receptors influences the outcome of viral infections. While Siglecs are needed to promote effective antiviral immune responses, they can also pave the way to viral dissemination within tissues. Here, we review how recent preclinical findings focusing on the interplay between Siglecs and viruses may translate into promising broad-spectrum therapeutic interventions or key biomarkers to monitor the course of viral infections.

引用

页数：12

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