Characteristics of Patients with Crohn's Disease With or Without Perianal Fistulae in the CorEvitas Inflammatory Bowel Disease Registry

被引:4
|
作者
Fan, Yanni [1 ]
Delgado-Aros, Silvia [2 ]
Valdecantos, Wendell C. [1 ]
Janak, Jud C. [3 ]
Moore, Page C. [3 ]
Crabtree, Margaux M. [3 ]
Stidham, Ryan W. [4 ]
机构
[1] Boehringer Ingelheim Pharmaceut Inc, 900 Ridgebury Rd, Ridgefield, CT 06877 USA
[2] Boehringer Ingelheim Int GmbH, Binger Str 173, D-55218 Ingelheim, Germany
[3] CorEvitas LLC, 1440 Main St, Waltham, MA 02451 USA
[4] Univ Michigan, Dept Internal Med, Div Gastroenterol & Hepatol, 500 S State St, Ann Arbor, MI 48109 USA
关键词
Crohn's disease; Perianal fistula; CorEvitas IBD Registry; INFLIXIMAB; DIAGNOSIS;
D O I
10.1007/s10620-022-07491-y
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background There are limited real-world data characterizing perianal fistulae in patients with Crohn's disease (CD). Aim To describe characteristics of patients with CD with and without perianal fistulae. Methods In this cross-sectional study, characteristics, treatment history, and health outcomes of patients with CD enrolled in the CorEvitas IBD Registry were described according to perianal fistula status (current/previous or none). Results Eight hundred and seventy-eight patients were included. Compared with patients with no perianal fistulae (n = 723), patients with current/previous perianal fistulae (n = 155) had longer disease duration since CD diagnosis (mean 16.5 vs 12.3 years; difference 4.3 years; 95% CI, 2.0, 6.6) and fewer had Harvey-Bradshaw Index scores indicative of remission (0-4, 56.8% vs 69.6%; difference - 12.9%; 95% CI, - 21.6, - 4.2). More patients with current/previous fistulae reported a history of IBD-related emergency room visits (67.7% vs 56.1%; difference 11.6%; 95% CI, 3.4, 19.8), hospitalizations (76.1% vs 58.4%; difference 17.7%; 95% CI, 10.1, 25.4), and surgeries (59.4% vs 27.7%; difference 31.7%; 95% CI, 23.3, 40.1), and a history of treatment with tumor necrosis factor inhibitors (81.3% vs 60.7%; difference 20.6%; 95% CI, 13.5, 27.7), immunosuppressants (51.6% vs 31.2%; difference 20.4%; 95% CI, 11.9, 29.0), and antibiotics (50.3% vs 23.7%; difference 26.6%; 95% CI, 18.2, 35.1) than patients without perianal fistulae. Conclusions Patients with CD with current/previous perianal fistulae have more symptomatic experiences of disease, higher medication use, hospitalization rates, and emergency room visits than patients without perianal fistulae. Interventions to prevent/reduce risk of developing fistulae may help improve outcomes in CD. [GRAPHICS] .
引用
收藏
页码:214 / 222
页数:9
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