Synthesis of Novel Diterpenic Peptides via the Ugi Reaction and Their Anticancer Activities

被引：4
|
作者：
Smirnova, Anna A. [1 ]
Zakirova, Liana M. [1 ]
Smirnova, Irina E. [1 ]
Tretyakova, Elena V. [1 ]
机构：
[1] Russian Acad Sci, Ufa Inst Chem, Ufa Fed Res Ctr, 71, Prospect Octyabrya, Ufa 450054, Russia
来源：
MOLBANK | 2023年 / 2023卷 / 03期
关键词：
diterpenes; dihydroquinopimaric acid; maleopimaric acid; peptides; Ugi reaction; anticancer activity; ABIETANE DITERPENOIDS; ACID; DERIVATIVES;
D O I：
10.3390/M1707
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Novel diterpenic peptide derivatives were synthesized via the Ugi four-component reaction at ambient temperature. The protocol employed a reaction between formaldehyde, benzyl amine, the corresponding diterpene acid, and ethyl 2-isocyanoacetate. The anticancer properties of the compounds were studied in vitro.
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页数：5
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