The Emerging Role of B1 SINE in Pluripotent Reprogramming

被引：0
|
作者：
Weltner, Jere [1 ,2 ]
Trokovic, Ras [1 ,3 ]
机构：
[1] Univ Helsinki, Stem Cells & Metab Res Program, Helsinki, Finland
[2] Folkhalsan Res Ctr, Helsinki, Finland
[3] Univ Helsinki, Stem Cells & Metab Res Program, Haartmaninkatu 8, Helsinki 00290, Finland
来源：
CELLULAR REPROGRAMMING | 2023年 / 25卷 / 03期
关键词：
reprogramming; CRISPR screen; ZFP266; B1; SINE; iPSC;
D O I：
10.1089/cell.2023.0037
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
By screening a CRISPR knockout library for mouse pluripotent reprogramming roadblock genes, Kaemena et al. identify the KRAB-ZFP factor Zfp266 as a suppressor of efficient reprogramming. Furthermore, by analyzing DNA binding and chromatin openness, the authors found that ZFP266 has a role in suppressing reprogramming by targeting the B1 SINE sequences for silencing.
引用
收藏
页码：88 / 90
页数：3
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