Clinical and immunological relevance of SLAMF6 expression in the tumor microenvironment of breast cancer and melanoma

被引:3
|
作者
Oba, Takaaki [1 ]
Long, Mark D. [2 ]
Ito, Ken-ichi [1 ]
Ito, Fumito [3 ]
机构
[1] Shinshu Univ, Dept Surg, Div Breast & Endocrine Surg, Sch Med, Matsumoto, Japan
[2] Roswell Pk Comprehens Canc Ctr, Dept Biostat & Bioinformat, Buffalo, NY USA
[3] Univ Southern Calif Los Angeles, Keck Sch Med, Dept Surg, 1450 Biggy St NRT 3505, Los Angeles, CA 90033 USA
来源
SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期
关键词
CD8(+) T-CELLS; DENDRITIC CELLS; INFILTRATING LYMPHOCYTES; IMMUNOTHERAPY; TRAFFICKING; BLOCKADE; IMMUNITY;
D O I
10.1038/s41598-023-50062-y
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Compelling evidence shows that the frequency of T cells in the tumor microenvironment correlates with prognosis as well as response to immunotherapy. However, considerable heterogeneity exists within tumor-infiltrating T cells, and significance of their genomic and transcriptomic landscape on clinical outcomes remains to be elucidated. Signaling lymphocyte activation molecule 6 (SLAMF6) is expressed on intra-tumoral progenitor-exhausted T cells, which exhibit the capacity to proliferate, self-renew and produce terminally-exhausted T cells in pre-clinical models and patients. Here, we investigated the impact of SLAMF6 expression on prognosis in two immunologically different tumor types using publicly available databases. Our findings demonstrate that high SLAMF6 expression is associated with better prognosis, expression of TCF7 (encoding T-cell factor 1), and increased gene signatures associated with conventional type 1 dendritic cells and effector function of T cells in melanoma and breast cancer. Single-cell profiling of breast cancer tumor microenvironment reveals SLAMF6 expression overlaps CD8 T cells with a T-effector signature, which includes subsets expressing TCF7, memory and effector-related genes, analogous to progenitor-exhausted T cells. These findings illustrate the significance of SLAMF6 in the tumor as a marker for better effector responses, and provide insights into the predictive and prognostic determinants for cancer patients.
引用
收藏
页数:10
相关论文
共 50 条
  • [21] Prognostic Relevance of IL-6 Expression in the Tumor Microenvironment of Classical Hodgkin Lymphoma
    Gholiha, Alex Reza
    Hollander, Peter
    Hedstrom, Gustaf
    Molin, Daniel
    Hjalgrim, Henrik
    Smedby, Karin Ekstrom
    Glimelius, Ingrid
    Hashemi, Jamileh
    Amini, Rose-Marie
    Enblad, Gunilla
    AMERICAN JOURNAL OF HEMATOLOGY, 2020, 95 : S14 - S15
  • [22] Gene expression profiling of the tumor microenvironment during breast cancer progression
    Xiao-Jun Ma
    Sonika Dahiya
    Elizabeth Richardson
    Mark Erlander
    Dennis C Sgroi
    Breast Cancer Research, 11
  • [23] Gene expression profiling of the tumor microenvironment during breast cancer progression
    Ma, Xiao-Jun
    Dahiya, Sonika
    Richardson, Elizabeth
    Erlander, Mark
    Sgroi, Dennis C.
    BREAST CANCER RESEARCH, 2009, 11 (01):
  • [24] Correction: Expression of hormone receptors is associated with specific immunological profiles of the breast cancer microenvironment
    Toru Hanamura
    Shigehisa Kitano
    Hiroshi Kagamu
    Makiko Yamashita
    Mayako Terao
    Takuho Okamura
    Nobue Kumaki
    Katsuto Hozumi
    Takayuki Iwamoto
    Chikako Honda
    Sasagu Kurozumi
    Naoki Niikura
    Breast Cancer Research, 25
  • [25] Multiomics characterization of pyroptosis in the tumor microenvironment and therapeutic relevance in metastatic melanoma
    Chen, Wenqiong
    He, Yi
    Zhou, Guowei
    Chen, Xiang
    Ye, Youqiong
    Zhang, Guanxiong
    Liu, Hong
    BMC MEDICINE, 2024, 22 (01)
  • [26] Heterogeneity of the tumor immune microenvironment and its clinical relevance
    Qingzhu Jia
    Aoyun Wang
    Yixiao Yuan
    Bo Zhu
    Haixia Long
    Experimental Hematology & Oncology, 11
  • [27] Heterogeneity of the tumor immune microenvironment and its clinical relevance
    Jia, Qingzhu
    Wang, Aoyun
    Yuan, Yixiao
    Zhu, Bo
    Long, Haixia
    EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2022, 11 (01)
  • [28] The tumor microenvironment and inflammatory breast cancer
    Huang, Aji
    Cao, Shousong
    Tang, Lili
    JOURNAL OF CANCER, 2017, 8 (10): : 1884 - 1891
  • [29] Multiomics characterization of pyroptosis in the tumor microenvironment and therapeutic relevance in metastatic melanoma
    Wenqiong Chen
    Yi He
    Guowei Zhou
    Xiang Chen
    Youqiong Ye
    Guanxiong Zhang
    Hong Liu
    BMC Medicine, 22
  • [30] Role of the Tumor Microenvironment in Breast Cancer
    Soysal, Savas D.
    Tzankov, Alexandar
    Muenst, Simone E.
    PATHOBIOLOGY, 2015, 82 (3-4) : 142 - 152