Nicotinamide mononucleotide, a potential future treatment in ocular diseases

被引:4
|
作者
Lee, Deokho [1 ,2 ]
Tomita, Yohei [1 ,2 ]
Shinojima, Ari [1 ,2 ]
Ban, Norimitsu [2 ]
Yamaguchi, Shintaro [3 ]
Nishioka, Ken [3 ]
Negishi, Kazuno [2 ]
Yoshino, Jun [3 ]
Kurihara, Toshihide [1 ,2 ]
机构
[1] Keio Univ, Lab Photobiol, Sch Med, Tokyo 1608582, Japan
[2] Keio Univ, Dept Ophthalmol, Sch Med, Tokyo 1608582, Japan
[3] Keio Univ, Dept Internal Med, Sch Med, Tokyo 1608582, Japan
关键词
Aging; Eye; Nicotinamide mononucleotide; Nicotinamide adenine dinucleotide; Ophthalmology; RETINAL-DETACHMENT; B-WAVE; CALORIE RESTRICTION; OXIDATIVE STRESS; DEGENERATION; NAD(+); MODEL; RESVERATROL; ELECTRORETINOGRAM; ACTIVATION;
D O I
10.1007/s00417-023-06118-w
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
PurposeThe burden of ocular diseases has been gradually increasing worldwide. Various factors are suggested for the development and progression of ocular diseases, such as ocular inflammation, oxidative stress, and complex metabolic dysregulation. Thus, managing ocular diseases requires the modulation of pathologic signaling pathways through many mechanisms. Nicotinamide mononucleotide (NMN) is a bioactive molecule naturally found in life forms. NMN is a direct precursor of the important molecule nicotinamide adenine dinucleotide (NAD(+)), an essential co-enzyme required for enormous cellular functions in most life forms. While the recent experimental evidence of NMN treatment in various metabolic diseases has been well-reviewed, NMN treatment in ocular diseases has not been comprehensively summarized yet. In this regard, we aimed to focus on the therapeutic roles of NMN treatment in various ocular diseases with recent advances.MethodsHow we came to our current opinion with a recent summary was described based on our own recent reports as well as a search of the related literature.ResultsWe found that NMN treatment might be available for the prevention of and protection from various experimental ocular diseases, as NMN treatment modulated ocular inflammation, oxidative stress, and complex metabolic dysregulation in murine models for eye diseases such as ischemic retinopathy, corneal defect, glaucoma, and age-related macular degeneration.ConclusionOur current review suggests and discusses new modes of actions of NMN for the prevention of and protection from various ocular diseases and can urge future research to obtain more solid evidence on a potential future NMN treatment in ocular diseases at the preclinical stages.
引用
收藏
页码:689 / 700
页数:12
相关论文
共 50 条
  • [31] OCULAR DISEASES AND THEIR TREATMENT
    NAUDE, L
    PHARMACY INTERNATIONAL, 1981, 2 (07): : 160 - 163
  • [32] Nicotinamide mononucleotide enhances the developmental potential of mouse early embryos exposed to perfluorooctanoic acid
    Zhang, Hanwen
    Li, Yu
    Li, Na
    Miao, Yilong
    Sun, Shaochen
    Gu, Ling
    Xiong, Bo
    REPRODUCTIVE TOXICOLOGY, 2025, 132
  • [33] Rat liver mitochondria can synthesize nicotinamide adenine dinucleotide from nicotinamide mononucleotide and ATP via a putative matrix nicotinamide mononucleotide adenylyltransferase.
    Barile, M
    Passarella, S
    Danese, G
    Quagliariello, E
    BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, 1996, 38 (02): : 297 - 306
  • [34] Metabolic design for selective production of nicotinamide mononucleotide from glucose and nicotinamide
    Shoji, Shinichiro
    Yamaji, Taiki
    Makino, Harumi
    Ishii, Jun
    Kondo, Akihiko
    METABOLIC ENGINEERING, 2021, 65 : 167 - 177
  • [35] Nicotinamide mononucleotide adenylyltransferase displays alternate binding modes for nicotinamide nucleotides
    Pfoh, Roland
    Pai, Emil F.
    Saridakis, Vivian
    ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2015, 71 : 2032 - 2039
  • [36] Nicotinamide mononucleotide adenylyltransferase displays alternate binding modes for nicotinamide nucleotides
    Saridakis, Vivian
    Christendat, Dinesh
    Bochkarev, Alexei
    Pai, Emil F.
    ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2011, 67 : C793 - C793
  • [37] Identification of a novel human nicotinamide mononucleotide adenylyltransferase
    Raffaelli, N
    Sorci, L
    Amici, A
    Emanuelli, M
    Mazzola, F
    Magni, G
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002, 297 (04) : 835 - 840
  • [38] Purification of human nicotinamide-mononucleotide adenylyltransferase
    Magni, G
    Emanuelli, M
    Amici, A
    Raffaelli, N
    Ruggieri, S
    VITAMINS AND COENZYMES, PT J, 1997, 280 : 241 - 247
  • [39] NICOTINAMIDE MONONUCLEOTIDE PYROPHOSPHORYLASE ACTIVITY OF ANIMAL TISSUE
    DIETRICH, LS
    FULLER, L
    MARTINEZ, L
    YERO, IL
    FEDERATION PROCEEDINGS, 1965, 24 (2P1) : 480 - &
  • [40] Identification of the nicotinamide mononucleotide adenylyltransferase of Trypanosoma cruzi
    Nino, Carlos H.
    Forero-Baena, Nicolas
    Contreras, Luis E.
    Sanchez-Lancheros, Diana
    Figarella, Katherine
    Ramirez, Maria H.
    MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2015, 110 (07): : 890 - 897