The dresden platform is a research hub for ultra-high dose rate radiobiology

被引：0

作者：

Metzkes-Ng, Josefine ^{[1
]}

Brack, Florian-Emanuel ^{[1
]}

Kroll, Florian ^{[1
]}

Bernert, Constantin ^{[1
,2
]}

Bock, Stefan ^{[1
]}

Bodenstein, Elisabeth ^{[1
,3
,4
]}

Brand, Michael ^{[5
,6
]}

Cowan, Thomas E. ^{[1
,2
]}

Gebhardt, Rene ^{[1
]}

Hans, Stefan ^{[5
,6
]}

Helbig, Uwe ^{[1
]}

Horst, Felix ^{[1
,3
,4
]}

Jansen, Jeannette ^{[7
,8
]}

Kraft, Stephan D. ^{[1
]}

Krause, Mechthild ^{[1
,3
,4
,9
,10
,11
,12
,13
,14
,15
,16
,17
]}

Lessmann, Elisabeth ^{[1
]}

Loeck, Steffen ^{[3
,4
,9
,10
,11
,12
]}

Pawelke, Joerg ^{[1
,3
,4
]}

Pueschel, Thomas ^{[1
]}

Reimold, Marvin ^{[1
]}

Rehwald, Martin ^{[1
]}

Richter, Christian ^{[1
,3
,4
,9
,10
,11
,12
]}

Schlenvoigt, Hans-Peter ^{[1
]}

Schramm, Ulrich ^{[1
,2
]}

Schuerer, Michael ^{[3
,4
,13
,14
,15
,16
,17
]}

Seco, Joao ^{[7
,18
]}

Szabo, Emilia Rita ^{[19
,20
]}

Umlandt, Marvin E. P. ^{[1
,2
]}

Zeil, Karl ^{[1
]}

Ziegler, Tim ^{[1
,2
]}

Beyreuther, Elke ^{[1
,3
,4
]}

机构：

[1] Helmholtz Zentrum Dresden Rossendorf, Dresden, Germany

[2] TUD Dresden Univ Technol, Dresden, Germany

[3] TUD Dresden Univ Technol, Fac Med, OncoRay Natl Ctr Radiat Res Oncol, Dresden, Germany

[4] TUD Dresden Univ Technol, Univ Hosp Carl Gustav Carus, Helmholtz Zentrum Dresden Rossendorf, Dresden, Germany

[5] TUD Dresden Univ Technol, Ctr Regenerat Therapies CRTD, Dresden, Germany

[6] TUD Dresden Univ Technol, Cluster Excellence Phys Life, Dresden, Germany

[7] German Canc Res Ctr, Heidelberg, Germany

[8] Ctr Hosp Univ Vaudois CHUV, Lausanne, Switzerland

[9] TUD Dresden Univ Technol, Dept Radiotherapy & Radiat Oncol, Fac Med, Dresden, Germany

[10] TUD Dresden Univ Technol, Univ Hosp Carl Gustav Carus, Dresden, Germany

[11] German Canc Consortium DKTK, Partner Site Dresden, Dresden, Germany

[12] German Canc Res Ctr, Heidelberg, Germany

[13] Natl Ctr Tumor Dis NCT UCC, Dresden, Germany

[14] German Canc Res Ctr, Heidelberg, Germany

[15] TUD Dresden Univ Technol, Med Fak, Dresden, Germany

[16] TUD Dresden Univ Technol, Univ Hosp Carl Gustav Carus, Dresden, Germany

[17] Helmholtz Zentrum Dresden Rossendorf, Dresden, Germany

[18] Ruprecht Karls Univ Heidelberg, Fac Phys & Astron, Heidelberg, Germany

[19] ELI HU Nonprofit Ltd, ELI ALPS, Szeged, Hungary

[20] Univ Szeged, Dept Oncotherapy, Szeged, Hungary

来源：

SCIENTIFIC REPORTS | 2023年 / 13卷 / 01期

基金：

欧盟地平线“2020”;

关键词：

D O I：

暂无

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The recently observed FLASH effect describes the observation of normal tissue protection by ultra-high dose rates (UHDR), or dose delivery in a fraction of a second, at similar tumor-killing efficacy of conventional dose delivery and promises great benefits for radiotherapy patients. Dedicated studies are now necessary to define a robust set of dose application parameters for FLASH radiotherapy and to identify underlying mechanisms. These studies require particle accelerators with variable temporal dose application characteristics for numerous radiation qualities, equipped for preclinical radiobiological research. Here we present the dresden platform, a research hub for ultra-high dose rate radiobiology. By uniting clinical and research accelerators with radiobiology infrastructure and know-how, the dresden platform offers a unique environment for studying the FLASH effect. We introduce its experimental capabilities and demonstrate the platform's suitability for systematic investigation of FLASH by presenting results from a concerted in vivo radiobiology study with zebrafish embryos. The comparative pre-clinical study was conducted across one electron and two proton accelerator facilities, including an advanced laser-driven proton source applied for FLASH-relevant in vivo irradiations for the first time. The data show a protective effect of UHDR irradiation up to 105Gy/s and suggests consistency of the protective effect even at escalated dose rates of 109Gy/s. With the first clinical FLASH studies underway, research facilities like the dresden platform, addressing the open questions surrounding FLASH, are essential to accelerate FLASH's translation into clinical practice.

引用

页数：12

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