Sarcoeleganolides H-K, new anti-thrombotic cembranes from soft coral Sarcophyton elegans

被引：0
|
作者：
Wang, Cili [1 ,2 ]
Zhang, Jiarui [1 ,2 ]
Jin, Tianyun [1 ,2 ]
Shi, Xing [1 ,2 ]
Wang, Mengfei [3 ]
Zhang, Wenjing [1 ,2 ]
Zong, Yuan [1 ,2 ]
Li, Guoqiang [1 ,2 ]
Li, Pinglin [1 ,2 ]
机构：
[1] Ocean Univ China, Minist Educ, Sch Med & Pharm, Key Lab Marine Drugs, Qingdao, Peoples R China
[2] Natl Lab Marine Sci & Technol, Lab Marine Drugs & Biol Prod, Qingdao, Peoples R China
[3] Qilu Univ Technol, Shandong Acad Sci, Biol Inst, Jinan, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2024年 / 38卷 / 20期
关键词：
Sarcophyton elegans; soft coral; new cembranes; Sarcoeleganolides H-K;
D O I：
10.1080/14786419.2023.2258436
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Chemical investigation of soft coral the Sarcophyton elegans collected from the South China Sea led to the identification of four new cembranes, namely sarcoeleganolides H-K (1-4). Their structures and absolute configurations were established by 1D and 2D NMR spectroscopy, quantum chemical calculations of NMR chemical shifts and electronic circular dichroism (ECD) data analysis. Moreover, compound 2 exhibited moderate anti-thrombotic activity in zebrafish.
引用
收藏
页码：3597 / 3604
页数：8
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