Eugenia sonderiana O. Berg leaves: Phytochemical characterization, evaluation of in vitro and in vivo antidiabetic effects, and structure-activity correlation

被引：4

作者：

Bastos, Renan G. ^{[1
]}

Rodrigues, Sarah de O. ^{[2
]}

Marques, Larissa A. ^{[3
]}

de Oliveira, Carla M. ^{[4
]}

Salles, Bruno C. C. ^{[4
]}

Zanatta, Ana C. ^{[4
]}

Rocha, Fabiola D. ^{[3
]}

Vilegas, Wagner ^{[2
]}

Pagnossa, Jorge P. ^{[2
]}

Paula, Fernanda B. de A. ^{[4
]}

da Silva, Geraldo A. ^{[1
]}

Batiha, Gaber E. ^{[5
]}

Aggad, Sarah S. ^{[6
]}

Alotaibi, Badriyah S. ^{[7
]}

Yousef, Fatimah M. ^{[6
]}

da Silva, Marcelo A. ^{[1
]}

机构：

[1] Univ Fed Alfenas, Fac Pharmaceut Sci, Dept Food & Drugs, Alfenas, Brazil

[2] Pontif Catholic Univ, Dept Biol Sci, Pocos De Caldas, Brazil

[3] Univ Fed Juiz de Fora, Juiz De Fora, Brazil

[4] Univ Fed Alfenas, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, Alfenas, Brazil

[5] Cairo Univ, Fac Vet Med, Dept Pharmacol & Therapeut, Giza, Egypt

[6] King Abdulaziz Univ, Fac Human Sci & Design, Dept Food & Nutr, Jeddah, Saudi Arabia

[7] Princess Nourah bint Abdulrahman Univ, Coll Pharm, Dept Pharmaceut Sci, POB 84428, Riyadh 11671, Saudi Arabia

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 165卷

关键词：

Eugenia sonderiana; Phytochemical characterization; Antidiabetic effects; Biocompounds; Antidiabetic activity; In vitro and in vivo experiments; ALPHA-GLUCOSIDASE; OXIDATIVE STRESS; ANTIOXIDATIVE ACTIVITY; LIPID-PEROXIDATION; INSULIN; EXTRACT; AMYLASE; MYRTACEAE; PROTEIN; ACID;

D O I：

10.1016/j.biopha.2023.115126

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Several medicinal plants have drawn the attention of researchers by its phytochemical composition regarding their potential for treating chronic complications of diabetes mellitus. In this context, plants of the Myrtaceae family popularly used in Brazil for the treatment of diabetes mellitus, including Eugenia sonderiana, have shown beneficial effects due to the presence of phenolic compounds and saponins in their chemical constitution. Thus, the present work aimed to perform the phytochemical characterization of the hydroethanolic extract of E. sonderiana leaves using high-performance liquid chromatography coupled with mass spectrometry (HPLC-MS), along with in vitro and in vivo studies of antidiabetic activity. The chemical characterization revealed the presence of phenolic compounds, flavonoids, neolignans, tannins, and saponins. In addition, the extract exhibited minimum inhibitory concentrations of alpha-amylase and alpha-glycosidase higher than the acarbose in the in vitro tests. Also, the in vivo tests revealed a slight increase in body mass in diabetic rats, as well as a significant decrease in water and feed consumption provided by the extract. Regarding serum biochemical parameters, the extract showed significant activity in decreasing the levels of glucose, hepatic enzymes, and triglycerides, in addition to maintaining HDL cholesterol levels within normal ranges, protecting the cell membranes against oxidative damage. Thus, the extract of E. sonderiana leaves was considered promising pharmaceutical ingredient in the production of a phytotherapy medication.

引用

页数：13

共 33 条

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