Visible-Light-Induced Four-Component Ritter-Type Reaction: Access to β-Trifluoromethyl Imides

被引：6
|
作者：
Ma, Ransong [1 ]
Ren, Yuanyuan [1 ]
Deng, Zhoubin [1 ]
Wang, Ke-Hu [1 ]
Wang, Junjiao [1 ]
Huang, Danfeng [1 ]
Lv, Xiaobo [3 ]
Hu, Yulai [1 ,2 ]
机构：
[1] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Gansu, Peoples R China
[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
[3] Shanghai Sinofluoro Chem Co Ltd, Shanghai 201321, Peoples R China
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 22期
基金：
中国国家自然科学基金;
关键词：
FUNCTIONALIZATION; ALKENES;
D O I：
10.1021/acs.orglett.3c01291
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A visible-light-induced four-component Ritter-type reactionwasdeveloped for the synthesis of beta-trifluoromethyl imides fromCF(3)Br, alkenes, carboxylic acids, and nitriles. This protocolfeatures mild reaction conditions, a broad substrate scope, and excellentfunctional group compatibility. Furthermore, this method has beenproven to be suitable for the late-stage diversification of drug molecules.A mechanism involving a Ritter-type reaction and Mumm rearrangementwas proposed on the basis of the control experiments.
引用
收藏
页码：4080 / 4085
页数：6
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