A metal-free protocol for the preparation of amines using ammonia borane under mild conditions

被引：6

作者：

Li, Xinmin ^{[1
,2
]}

Hu, Yue ^{[2
]}

Alenad, Asma M. ^{[3
]}

Zhou, Bei ^{[2
]}

Ma, Zhuang ^{[2
]}

Gao, Jie ^{[2
]}

Jagadeesh, Rajenahally V. ^{[2
]}

Beller, Matthias ^{[2
]}

机构：

[1] Zunyi Med Univ, Sch Pharm, Xuefu West Rd 6, Zunyi 563000, Peoples R China

[2] Leibniz Leibniz Inst Katalyse e V, Albert Einstein Str 29A, D-18059 Rostock, Germany

[3] Jouf Univ, Coll Sci, Chem Dept, PO Box 2014, Sakaka, Saudi Arabia

来源：

ORGANIC CHEMISTRY FRONTIERS | 2023年 / 10卷 / 04期

基金：

欧洲研究理事会; 中国国家自然科学基金;

关键词：

CATALYZED REDUCTIVE AMINATION; SECONDARY-AMINES; FORMIC-ACID; GENERAL-SYNTHESIS; HYDROGEN; ALDEHYDES; KETONES; IRON; NITROARENES;

D O I：

10.1039/d2qo01938h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and convenient reductive amination protocol for the synthesis of structurally diverse secondary and tertiary amines as well as N-methylated products under metal-free conditions is presented. This one-pot protocol works efficiently at room temperature using ammonia borane as the reductant and is applicable to a wide range of substrates, including chiral amines and amino acid derivatives. The synthetic utility and practicability of this methodology is demonstrated by gram-scale reactions and selected synthesis of current drug molecules.

引用

页码：970 / 976

页数：7

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