Pd(II)-Catalyzed Three-Component Synthesis of Furo[2,3-d]pyrimidines from β-Ketodinitriles, Boronic Acids, and Aldehydes

被引：2

作者：

Dhara, Hirendra Nath ^{[1
]}

Das, Bubul ^{[1
]}

Barik, Dinabandhu ^{[1
]}

Manna, Supriya ^{[1
]}

Patel, Bhisma K. ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, North Guwahati 781039, India

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 50期

关键词：

CONSTRUCTION; DERIVATIVES; ALKYNES; FURAN; ADDITION/CYCLIZATION; INHIBITORS; DISCOVERY; ACCESS; KINASE;

D O I：

10.1021/acs.orglett.3c04017

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Pd-(II)-catalyzed three-component synthesis of 2,4,6-triarylfuro-[2,3-d]-pyrimidines from beta-ketodinitriles, boronic acids, and aldehydes has been developed. The participation of both nitrile (-CN) groups led to the concurrent construction of furo-pyrimidine via the formation of C-C, (CC)-C-, C-O, C-N, and (CN)-N- bonds. The compounds show excellent photoluminescence properties with absorption maxima ranging from 348 to 387 nm and emission from 468 to 533 nm. The synthetic utility of the protocol was further demonstrated through a few postsynthetic manipulations.

引用

页码：9070 / 9075

页数：6

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