Histoplasmosis in Solid Organ Transplantation

被引:1
|
作者
Barros, Nicolas [1 ,2 ,3 ]
Wheat, L. Joseph [3 ]
机构
[1] Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA
[2] Indiana Univ Hlth, Div Infect Dis, Indianapolis, IN 46202 USA
[3] Miravista Diagnost, Indianapolis, IN 46241 USA
关键词
histoplasmosis; Histoplasma; solid organ transplant; transplant; IMMUNE RECONSTITUTION SYNDROME; INVASIVE FUNGAL DISEASE; CROSS-REACTIVITY; ENZYME-IMMUNOASSAY; CAPSULATUM ANTIGEN; AMPHOTERICIN-B; PULMONARY HISTOPLASMOSIS; DIAGNOSIS; RECIPIENTS; EPIDEMIOLOGY;
D O I
10.3390/jof10020124
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Histoplasma capsulatum, the etiological agent for histoplasmosis, is a dimorphic fungus that grows as a mold in the environment and as a yeast in human tissues. It has a broad global distribution with shifting epidemiology during recent decades. While in immunocompetent individuals infection is usually self-resolving, solid organ transplant recipients are at increased risk of symptomatic disease with dissemination to extrapulmonary tissue. Diagnosis of histoplasmosis relies on direct observation of the pathogen (histopathology, cytopathology, and culture) or detection of antigens, antibodies, or nucleic acids. All transplant recipients with histoplasmosis warrant therapy, though the agent of choice and duration of therapy depends on the severity of disease. In the present article, we describe the pathogenesis, epidemiology, clinical manifestations and management of histoplasmosis in solid organ transplant recipients.
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页数:20
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