Humoral immune response to COVID-19 vaccine in patients with myasthenia gravis

被引：2

作者：

Holm-Yildiz, Sonja ^{[1
,10
]}

Dysgaard, Tina ^{[1
]}

Krag, Thomas ^{[1
]}

Pedersen, Britt Staevnsbo ^{[1
]}

Hamm, Sebastian Rask ^{[2
]}

Perez-Alos, Laura ^{[3
]}

Hansen, Cecilie Bo ^{[3
]}

Pries-Heje, Mia Marie ^{[4
]}

Heftdal, Line Dam ^{[2
]}

Hasselbalch, Rasmus Bo ^{[5
]}

Fogh, Kamille ^{[5
]}

Madsen, Johannes Roth ^{[3
]}

Frikke-Schmidt, Ruth ^{[6
,7
]}

Hilsted, Linda Maria ^{[6
]}

Sorensen, Erik ^{[8
]}

Ostrowski, Sisse Rye ^{[7
,8
]}

Bundgaard, Henning ^{[4
,7
]}

Garred, Peter ^{[3
,7
]}

Iversen, Kasper ^{[5
,7
,9
]}

Nielsen, Susanne Dam ^{[2
]}

Vissing, John ^{[1
]}

机构：

[1] Univ Copenhagen, Copenhagen Neuromuscular Ctr, Righosp, Dept Neurol, Copenhagen, Denmark

[2] Copenhagen Univ Hosp, Dept Infect Dis, Rigshosp, Viro Immunol Res Unit, Copenhagen, Denmark

[3] Copenhagen Univ Hosp, Dept Clin Immunol, Righosp, Lab Mol Med, Sect 7631, Copenhagen, Denmark

[4] Copenhagen Univ Hosp, Dept Cardiol, Rigshosp, Copenhagen, Denmark

[5] Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Cardiol, Copenhagen, Denmark

[6] Copenhagen Univ Hosp, Dept Clin Biochem, Rigshosp, Copenhagen, Denmark

[7] Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark

[8] Copenhagen Univ Hosp, Dept Clin Immunol, Rigshosp, Copenhagen, Denmark

[9] Copenhagen Univ Hosp, Herlev & Gentofte Hosp, Dept Emergency Med, Copenhagen, Denmark

[10] Rigshosp, Dept Neurol 8077, Inge Lehmanns Vej 8, DK-2100 Copenhagen, Denmark

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2023年 / 384卷

关键词：

Myasthenia gravis; COVID-19; vaccine; BNT162b2; Humoral response; TETANUS;

D O I：

10.1016/j.jneuroim.2023.578215

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated the humoral response to the Pfizer-BioNTech COVID-19 (BNT162b2) vaccine in patients with myasthenia gravis on or off immunosuppressants and compared this to the response in healthy individuals. The SARS-CoV-2 IgG response and neutralizing capacity were measured in 83 patients (57 on immunosuppressants) and 332 healthy controls at baseline, three weeks, and two and six months after the vaccine. We found that the proportion of positive humoral response was lower in patients on immunosuppressants vs. controls at three weeks and two months (p <= 0.001), but not at six months post-vaccination (p = 0.379).

引用

页数：5

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