Can Neurofilament Light Chain Be Utilized as a Biomarker of Disease Severity, Activity, and Outcomes in Anti-NMDA Receptor Encephalitis?

被引：0

作者：

Kunchok, Amy ^{[1
]}

Dalmau, Josep ^{[2
]}

机构：

[1] Cleveland Clin, Neurol Inst, Mellen Ctr, Cleveland Hts, OH 44195 USA

[2] Univ Barcelona, Neurol Hosp Clin IDIBAPS, Barcelona, Spain

来源：

NEUROLOGY | 2023年 / 100卷 / 21期

关键词：

DIAGNOSIS;

D O I：

10.1212/WNL.0000000000207310

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Anti-NMDA receptor encephalitis (anti-NMDARe) is a disorder characterized by a combination of behavioral, cognitive, and psychiatric alterations along with seizures, abnormal movements, dysautonomia, or a decreased level of consciousness that sequentially develop over several weeks in association with NMDAR-IgG in cerebrospinal fluid (CSF).(1) This presentation is followed by weeks or months of persistent symptoms, often requiring intensive care (ICU), followed by a protracted recovery. Changes in CSF antibody titers may correlate with relapse, but serum titers are not reliable longitudinal biomarkers of disease activity.(2)

引用

页码：991 / 992

页数：2

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