Numerous emerging pollutants, including pharmaceutical compounds, dyes, personal care products, endocrinedisrupting chemicals, and pesticides, are increasingly found in landfill leachates, groundwater, and surface water systems. Their persistence, bioaccumulation, and toxicity, even at low concentrations, represent a major environmental and human health concern. So far, diverse degradation treatment processes have been explored; enzyme -assisted methodologies have been recognized as greener, safer, less expensive, and eco-friendly alternatives. However, the limited reusability and instability of natural enzymes under typical harsh environmental conditions significantly hinder applicability. Thus, different strategies have emerged, such as the design of engineered modified enzymes, the immobilization of enzymes on nanomaterials, and the development of artificial enzymes. Nanomaterials with enzyme -like activities have emerged as artificial enzymatic tools that catalytically degrade toxic pollutants. Recent studies have reported excellent performances of enzymes in the removal of emerging contaminants. This review thoroughly examines the most recent developments in the use of nanozymes for the remediation of various aquatic matrices. We finalize by discussing the current challenges faced by nanozymology for water remediation treatments to provide insight into potential future research directions.