YPD-30, a prodrug of YPD-29B, is an oral small-molecule inhibitor targeting PD-L1 for the treatment of human cancer (vol 12, pg 2845, 2022)

被引：0
|
作者：
Lai, Fangfang [1 ]
Ji, Ming [1 ]
Huang, Lei [1 ]
Wang, Yunchen [1 ]
Xue, Nina [1 ]
Du, Tingting [1 ]
Dong, Kai [3 ]
Yao, Xiaoqing [3 ]
Jin, Jing [1 ]
Feng, Zhiqiang [2 ]
Chen, Xiaoguang [1 ]
机构：
[1] Chinese Acad Med Sci Peking Union Med Coll, Inst Mat Med, Dept Pharmacol, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Dept Pharmacochem, Beijing 100050, Peoples R China
[3] Tianjin Chase Sun Pharmaceut Co Ltd, Tianjin 300170, Peoples R China
来源：
ACTA PHARMACEUTICA SINICA B | 2023年 / 13卷 / 07期
关键词：
D O I：
10.1016/j.apsb.2023.05.003
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：3178 / 3179
页数：2
相关论文
共 12 条
  • [1] YPD-30, a prodrug of YPD-29B, is an oral small-molecule inhibitor targeting PD-L1 for the treatment of human cancer
    Fangfang Lai
    Ming Ji
    Lei Huang
    Yunchen Wang
    Nina Xue
    Tingting Du
    Kai Dong
    Xiaoqing Yao
    Jing Jin
    Zhiqiang Feng
    Xiaoguang Chen
    ActaPharmaceuticaSinicaB, 2022, 12 (06) : 2845 - 2858
  • [2] YPD-30, a prodrug of YPD-29B, is an oral small-molecule inhibitor targeting PD-L1 for the treatment of human cancer
    Lai, Fangfang
    Ji, Ming
    Huang, Lei
    Wang, Yunchen
    Xue, Nina
    Du, Tingting
    Dong, Kai
    Yao, Xiaoqing
    Jin, Jing
    Feng, Zhiqiang
    Chen, Xiaoguang
    ACTA PHARMACEUTICA SINICA B, 2022, 12 (06) : 2845 - 2858
  • [3] Small-molecule inhibitor PD-1 /PD-L1 interaction for colorectal cancer treatment
    Anaya-Ruiz, Maricruz
    Perez-Santos, Martin
    PHARMACEUTICAL PATENT ANALYST, 2021, 10 (06) : 245 - 250
  • [4] ORAL SMALL-MOLECULE LIVER-TROPIC PD-L1 INHIBITOR PHARMACOKINETICS FOR THE TREATMENT OF HEPATOCELLULAR CARCINOMA
    Mondal, Arpita
    Thi, Emily P.
    Graves, Ingrid
    Heffernan, Gavin
    Xu, Fran
    Ozturk, Seyma
    Pohl, Amanda
    Fan, Kristi Y.
    Cole, Andrew
    Harasym, Troy
    Lam, Angela M.
    Sofia, Michael J.
    HEPATOLOGY, 2023, 78 : S1946 - S1947
  • [5] DISCOVERY OF A LIVER TARGETED ORAL PD-L1 SMALL MOLECULE INHIBITOR FOR THE TREATMENT OF CHRONIC HEPATITIS B AND LIVER CANCER
    Roose, Heleen
    Rekstyte-Matiene, Kristina
    Stevens, Sarah K.
    Gupta, Kusum
    Chang, Sandra
    Liu, Cheng
    Serebryany, Vladimir
    Adame, Lillian
    Le, Kha
    Stoycheva, Antitsa
    Blatt, Lawrence M.
    Beigelman, Leonid N.
    Chanda, Sushmita
    Smith, David B.
    Symons, Julian
    Jekle, Andreas
    Wu, Tongfei
    HEPATOLOGY, 2023, 78 : S566 - S567
  • [6] Targeting colorectal cancer with small-molecule inhibitors of ALDH1B1 (vol 18, pg 1065, 2022)
    Feng, Zhiping
    Hom, Marisa E.
    Bearrood, Thomas E.
    Rosenthal, Zachary C.
    Fernandez, Daniel
    Ondrus, Alison E.
    Gu, Yuchao
    Mccormick, Aaron K.
    Tomaske, Madeline G.
    Marshall, Cody R.
    Kline, Toni
    Chen, Che-Hong
    Mochly-Rosen, Daria
    Kuo, Calvin J.
    Chen, James K.
    NATURE CHEMICAL BIOLOGY, 2025, 21 (02) : 309 - 309
  • [7] Simultaneous Determination of a Novel PD-L1 Inhibitor, IMMH-010, and Its Active Metabolite, YPD-29B, in Rat Biological Matrices by Polarity-Switching Liquid Chromatography-Tandem Mass Spectrometry: Application to ADME Studies
    Jiang, Jianwei
    Zou, Xiaowen
    Liu, Yuke
    Liu, Xiao
    Dong, Kai
    Yao, Xiaoqing
    Feng, Zhiqiang
    Chen, Xiaoguang
    Sheng, Li
    Li, Yan
    FRONTIERS IN PHARMACOLOGY, 2021, 12
  • [8] First-in-human dose-escalating study of ABSK043, a novel and oral small-molecule inhibitor of PD-L1, in patients with advanced solid tumors
    Cooper, A.
    Andelkovic, V.
    Wilkinson, K.
    Ganju, V.
    Lundy, J.
    Hong, M.
    Airey, S.
    Meng, L. L.
    Shen, B.
    Li, H.
    Yao, L.
    Zhang, M.
    Coward, J.
    ANNALS OF ONCOLOGY, 2023, 34 : S487 - S487
  • [9] COMBINATION TREATMENT WITH HBV-TARGETING GALNAC-siRNA AND SMALL-MOLECULE PD-L1 INHIBITOR INCREASES HBV-SPECIFIC IMMUNE RESPONSES IN A CHRONIC HEPATITIS B INFECTION MOUSE MODEL
    Thi, Emily P.
    Graves, Ingrid
    Mondal, Arpita
    Cole, Andrew G.
    Heffernan, Gavin
    Iott, Christina L.
    Ozturk, Seyma
    Ganchua, Sharie C.
    Nguyen, Dan
    Stever, Kim
    Fan, Kristi
    Quintero, Jorge G.
    Kultgen, Steven G.
    Pohl, Amanda
    Harasym, Troy
    Lam, Angela M.
    Sofia, Michael J.
    HEPATOLOGY, 2022, 76 : S327 - S327
  • [10] RETRACTION: Clinical Efficacy and Safety Analysis of PD-1/PD-L1 Inhibitor vs. Chemotherapy in the Treatment of Advanced Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis (Retraction of Vol 2022, art no 9500319, 2022)
    Guo, W. -W.
    Zhang, T. -W.
    Wang, B. -L.
    Mao, L. -Q.
    Li, X. -B.
    BIOMED RESEARCH INTERNATIONAL, 2022, 2022
12