Recent advances in antibody glycoengineering for the of functions

被引：0
|
作者：
Liu, Zhi [1 ,2 ,3 ]
Zou, Xiangman [1 ]
Tang, Feng [1 ]
Huang, Wei [1 ,2 ,3 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Biotherapeut Discovery Res, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
[2] Lingang Lab, Shanghai 200031, Peoples R China
[3] ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2024年 / 78卷
关键词：
Antibody glycoengineering; Endoglycosidase; Chemo-enzymatic; Glycosyltransferase; Antibody-drug conjugates; HOST-CELL LINE; GLYCAN STRUCTURE; CHEMOENZYMATIC SYNTHESIS; GLYCOSYNTHASE MUTANTS; N-ACETYLGLUCOSAMINE; IGG ANTIBODIES; GLYCOSYLATION; SITE; ENDOGLYCOSIDASE; SIALYLATION;
D O I：
10.1016/j.cbpa.2023.102420
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Glycans play important roles in antibody functions, and antibody glycoengineering has long been an important research field. Here, we summarize the significant strategies of antibody glycoengineering, including expressed antibody glycoengineering in mammalian cell expression systems, chemoenzymatic antibody glycoengineering, and yeast expression system -based antibody engineering, as well as the applications of glycoengineering in antibody -drug conjugates. These advances in antibody glycoengineering will provide a comprehensive understanding and inspire us to develop more advanced techniques to achieve glycoengineered antibodies.
引用
收藏
页数：10
相关论文
共 50 条
  • [31] The interplay of protein engineering and glycoengineering to fine-tune antibody glycosylation and its impact on effector functions
    Wang, Qiong
    Wang, Tiexin
    Zhang, Roushu
    Yang, Shuang
    McFarland, Kevin S.
    Chung, Cheng-Yu
    Jia, Hongpeng
    Wang, Lai-Xi
    Cipollo, John F.
    Betenbaugh, Michael J.
    [J]. BIOTECHNOLOGY AND BIOENGINEERING, 2022, 119 (01) : 102 - 117
  • [32] Recent Advances in Monoclonal Antibody Therapies for Multiple Sclerosis
    Wootla, Bharath
    Watzlawik, Jens O.
    Stavropoulos, Nikolaos
    Wittenberg, Nathan J.
    Dasari, Harika
    Abdelrahim, Murtada A.
    Henley, John R.
    Oh, Sang-Hyun
    Warrington, Arthur E.
    Rodriguez, Moses
    [J]. EXPERT OPINION ON BIOLOGICAL THERAPY, 2016, 16 (06) : 827 - 839
  • [33] Recent advances in antiphospholipid antibody-related valvulopathies
    Cervera, R
    [J]. JOURNAL OF AUTOIMMUNITY, 2000, 15 (02) : 123 - 125
  • [34] Antibody-drug conjugates: Recent advances in payloads
    Wang, Zhijia
    Li, Hanxuan
    Gou, Lantu
    Li, Wei
    Wang, Yuxi
    [J]. ACTA PHARMACEUTICA SINICA B, 2023, 13 (10) : 4025 - 4059
  • [35] Antibody-drug conjugates: Recent advances in payloads
    Zhijia Wang
    Hanxuan Li
    Lantu Gou
    Wei Li
    Yuxi Wang
    [J]. Acta Pharmaceutica Sinica B, 2023, (10) : 4025 - 4059
  • [36] Recent advances in antibody drug conjugates for cancer therapy
    Meyer, DL
    Senter, PD
    [J]. ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 38, 2003, 38 : 229 - 237
  • [37] Recent advances in recombinant antibody technology: Part 2
    Morrow, KJ
    [J]. AMERICAN LABORATORY, 2000, 32 (14) : 13 - +
  • [38] Recent advances of antibody drug conjugates for clinical applications
    Pengxuan Zhao
    Yuebao Zhang
    Wenqing Li
    Christopher Jeanty
    Guangya Xiang
    Yizhou Dong
    [J]. Acta Pharmaceutica Sinica B, 2020, 10 (09) : 1589 - 1600
  • [39] Recent Advances in Monoclonal Antibody Therapy for Colorectal Cancers
    Hwang, Kyusang
    Yoon, Jin Hwan
    Lee, Ji Hyun
    Lee, Sukmook
    [J]. BIOMEDICINES, 2021, 9 (01) : 1 - 24
  • [40] Recent Advances in Antibody-Drug Conjugates for Lymphoma
    Russler-Germain, David A.
    Kahl, Brad S.
    [J]. ONCOLOGY-NEW YORK, 2020, 34 (12): : 522 - +
12345