Recent advances in antibody glycoengineering for the of functions

被引：0

作者：

Liu, Zhi ^{[1
,2
,3
]}

Zou, Xiangman ^{[1
]}

Tang, Feng ^{[1
]}

Huang, Wei ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Biotherapeut Discovery Res, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China

[2] Lingang Lab, Shanghai 200031, Peoples R China

[3] ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2024年 / 78卷

关键词：

Antibody glycoengineering; Endoglycosidase; Chemo-enzymatic; Glycosyltransferase; Antibody-drug conjugates; HOST-CELL LINE; GLYCAN STRUCTURE; CHEMOENZYMATIC SYNTHESIS; GLYCOSYNTHASE MUTANTS; N-ACETYLGLUCOSAMINE; IGG ANTIBODIES; GLYCOSYLATION; SITE; ENDOGLYCOSIDASE; SIALYLATION;

D O I：

10.1016/j.cbpa.2023.102420

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycans play important roles in antibody functions, and antibody glycoengineering has long been an important research field. Here, we summarize the significant strategies of antibody glycoengineering, including expressed antibody glycoengineering in mammalian cell expression systems, chemoenzymatic antibody glycoengineering, and yeast expression system -based antibody engineering, as well as the applications of glycoengineering in antibody -drug conjugates. These advances in antibody glycoengineering will provide a comprehensive understanding and inspire us to develop more advanced techniques to achieve glycoengineered antibodies.

引用

页数：10

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