Seven drimane-type sesquiterpenoids from an earwig-associated Aspergillus sp.

被引：7
|
作者：
Salman, Khan [1 ]
Zhu, Hongjie [1 ]
Sun, Ziqian [1 ]
Li, Yilin [3 ,4 ]
Wang, Lan [1 ]
Wang, Rong [4 ]
Guo, Zhikai [2 ,3 ]
Jiao, Ruihua [1 ]
机构：
[1] Nanjing Univ, Inst Funct Biomol, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China
[2] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Trop Microbe Resources, Haikou 571101, Peoples R China
[3] Hainan Inst Trop Agr Resources, Key Lab Biol & Genet Resources Trop Crops Hainan P, Haikou 571101, Peoples R China
[4] Hainan Trop Ocean Univ, Hainan Acad Ocean & Fisheries Sci, Haikou 571126, Peoples R China
来源：
CHINESE JOURNAL OF NATURAL MEDICINES | 2023年 / 21卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Fungus; Sesquiterpenoids; Drimane-type; Antibacterial; Cytotoxic; Aspergillus sp; DERIVATIVES;
D O I：
10.1016/S1875-5364(23)60385-1
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Drimane-type sesquiterpenoids are widely distributed in fungi. From the ethyl acetate extract of the earwig-derived As-pergillus sp. NF2396, seven new drimane-type sesquiterpenoids, named drimanenoids A-G (1-7), were isolated. Their structures were elucidated by diverse spectroscopic analysis including high-resolution ESI-MS, one-and two-dimensional NMR spectroscopy. Drim-anenoids A-F (1-6) are new members of drimane-type sesquiterpenoid esterified with unsaturated fatty acid side chain at C-6. Drim-anenoids C (3), D (4) and F (6) showed antibacterial activity against five types of bacteria with different inhibition diameters. Drim-anenoid D (4) exhibited moderate cytotoxicity against human myelogenous leukemia cell line K562 with an IC50 value of 12.88 +/- 0.11 mu mol center dot L-1.
引用
收藏
页码：58 / 64
页数：7
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