Seven drimane-type sesquiterpenoids from an earwig-associated Aspergillus sp.

被引：7

作者：

Salman, Khan ^{[1
]}

Zhu, Hongjie ^{[1
]}

Sun, Ziqian ^{[1
]}

Li, Yilin ^{[3
,4
]}

Wang, Lan ^{[1
]}

Wang, Rong ^{[4
]}

Guo, Zhikai ^{[2
,3
]}

Jiao, Ruihua ^{[1
]}

机构：

[1] Nanjing Univ, Inst Funct Biomol, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China

[2] Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Trop Microbe Resources, Haikou 571101, Peoples R China

[3] Hainan Inst Trop Agr Resources, Key Lab Biol & Genet Resources Trop Crops Hainan P, Haikou 571101, Peoples R China

[4] Hainan Trop Ocean Univ, Hainan Acad Ocean & Fisheries Sci, Haikou 571126, Peoples R China

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2023年 / 21卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Fungus; Sesquiterpenoids; Drimane-type; Antibacterial; Cytotoxic; Aspergillus sp; DERIVATIVES;

D O I：

10.1016/S1875-5364(23)60385-1

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Drimane-type sesquiterpenoids are widely distributed in fungi. From the ethyl acetate extract of the earwig-derived As-pergillus sp. NF2396, seven new drimane-type sesquiterpenoids, named drimanenoids A-G (1-7), were isolated. Their structures were elucidated by diverse spectroscopic analysis including high-resolution ESI-MS, one-and two-dimensional NMR spectroscopy. Drim-anenoids A-F (1-6) are new members of drimane-type sesquiterpenoid esterified with unsaturated fatty acid side chain at C-6. Drim-anenoids C (3), D (4) and F (6) showed antibacterial activity against five types of bacteria with different inhibition diameters. Drim-anenoid D (4) exhibited moderate cytotoxicity against human myelogenous leukemia cell line K562 with an IC50 value of 12.88 +/- 0.11 mu mol center dot L-1.

引用

页码：58 / 64

页数：7

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