A mechanistic blueprint for enzymatic reduction by a modular polyketide synthase

被引：0
|
作者：
Fraley, Amy E. [1 ]
机构：
[1] Eidgenoss TH ETH Zurich, Inst Microbiol, Zurich, Switzerland
来源：
STRUCTURE | 2023年 / 31卷 / 09期
关键词：
D O I：
10.1016/j.str.2023.08.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this issue of Structure, McCullough et al. describe linker peptides that serve as a "hydrophobic glue"to arrange the domains within the reducing region of a modular polyketide synthase. Comparisons to structural data from other megasynthases identified features that are unique to modular systems.
引用
收藏
页码：1013 / 1015
页数：3
相关论文
共 50 条
  • [1] Analysis of the enzymatic domains in the modular portion of the coronafacic acid polyketide synthase
    Jiralerspong, S
    Rangaswamy, V
    Bender, CL
    Parry, RJ
    GENE, 2001, 270 (1-2) : 191 - 200
  • [2] Structure of a modular polyketide synthase
    Somnath Dutta
    Jonathan R. Whicher
    Douglas A. Hansen
    Wendi A. Hale
    Joseph A. Chemler
    Grady R. Congdon
    Alison R. H. Narayan
    Kristina Håkansson
    David H. Sherman
    Janet L. Smith
    Georgios Skiniotis
    Nature, 2014, 510 : 512 - 517
  • [3] Structure of a modular polyketide synthase
    Dutta, Somnath
    Whicher, Jonathan R.
    Hansen, Douglas A.
    Hale, Wendi A.
    Chemler, Joseph A.
    Congdon, Grady R.
    Narayan, Alison R. H.
    Hakansson, Kristina
    Sherman, David H.
    Smith, Janet L.
    Skiniotis, Georgios
    NATURE, 2014, 510 (7506) : 512 - +
  • [4] POLYKETIDE SYNTHESIS IN-VITRO ON A MODULAR POLYKETIDE SYNTHASE
    WIESMANN, KEH
    CORTES, J
    BROWN, MJB
    CUTTER, AL
    STAUNTON, J
    LEADLAY, PF
    CHEMISTRY & BIOLOGY, 1995, 2 (09): : 583 - 589
  • [5] Characterization of the enzymatic domains in the modular polyketide synthase involved in rifamycin B biosynthesis by Amycolatopsis mediterranei
    Tang, L
    Yoon, YJ
    Choi, CY
    Hutchinson, CR
    GENE, 1998, 216 (02) : 255 - 265
  • [6] Macrodiolide Formation by the Thioesterase of a Modular Polyketide Synthase
    Zhou, Yongjun
    Prediger, Patricia
    Dias, Luiz Carlos
    Murphy, Annabel C.
    Leadlay, Peter F.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 54 (17) : 5232 - 5235
  • [7] Structure of a modular polyketide synthase reducing region
    McCullough, Tyler M.
    Dhar, Anya
    Akey, David L.
    Konwerski, Jamie R.
    Sherman, David H.
    Smith, Janet L.
    STRUCTURE, 2023, 31 (09) : 1109 - +
  • [8] Insights into the stereospecificity of ketoreduction in a modular polyketide synthase
    Kwan, David H.
    Tosin, Manuela
    Schlaeger, Nadin
    Schulz, Frank
    Leadlay, Peter F.
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2011, 9 (07) : 2053 - 2056
  • [9] Programming of Erythromycin Biosynthesis by a Modular Polyketide Synthase
    Cane, David E.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (36) : 27517 - 27523
  • [10] Engineering of polyketide biosynthesis by domain replacements in a modular polyketide synthase.
    Oliynyk, M
    Brown, MJB
    Leadlay, PF
    FASEB JOURNAL, 1997, 11 (09): : A1310 - A1310
12345