Impacts of whole-body vibration on denervated skeletal-muscle atrophy in rats

被引:1
|
作者
Koh, Eun Sil [1 ]
Lim, Jae-Young [2 ,3 ,4 ]
机构
[1] Natl Med Ctr, Dept Rehabil Med, Seoul, South Korea
[2] Seoul Natl Univ, Bundang Hosp, Dept Rehabil Med, Coll Med, Seongnam, South Korea
[3] Seoul Natl Univ, Inst Aging, Seoul, South Korea
[4] Seoul Natl Univ, Coll Med, Dept Rehabil Med, 82 Gumi Ro 173 Beon Gil, Seongnam 13620, South Korea
基金
新加坡国家研究基金会;
关键词
denervation; muscle atrophy; myosin heavy chain; whole-body vibration; HEAVY-CHAIN ISOFORMS; SPINAL-CORD-INJURY; ELECTRICAL-STIMULATION; SHORTENING VELOCITY; LARYNGEAL MUSCLE; SINGLE FIBERS; MYOSIN; EXPRESSION; APOPTOSIS; STRENGTH;
D O I
10.1002/jor.25589
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
Whole-body vibration has been considered as a countermeasure against muscle atrophy. However, its effects on muscle atrophy are poorly understood. We evaluated the effects of whole-body vibration on denervated skeletal muscle atrophy. Whole-body vibration was performed on rats from Day 15 to 28 after denervation injury. Motor performance was evaluated using an inclined-plane test. Compound muscle action potentials of the tibial nerve were examined. Muscle wet weight and muscle fiber cross-sectional area were measured. Myosin heavy chain isoforms were analyzed in both muscle homogenates and single myofibers. Whole-body vibration resulted in a significantly decreased inclination angle and muscle weight, but not muscle fiber cross-sectional area of fast-twitch gastrocnemius compared to denervation only. In denervated gastrocnemius, a fast-to-slow shift was observed in myosin heavy chain isoform composition following whole-body vibration. There were no significant changes in muscle weight, muscle fiber cross-sectional area, and myosin heavy chain isoform composition in denervated slow-twitch soleus. These results imply that whole-body vibration does not promote recovery of denervation-induced muscle atrophy.
引用
收藏
页码:2579 / 2587
页数:9
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