New bisabolane-type sesquiterpenoid from Aspergillus sydowii BTBU20213012

被引：2

作者：

Zhang, Xinjun ^{[1
]}

Dong, Yifei ^{[2
,3
]}

Liu, Xinyu ^{[2
,3
]}

Wang, Ruihong ^{[1
]}

Lu, Jie ^{[1
]}

Song, Fuhang ^{[2
,3
]}

机构：

[1] Tibet Agr & Anim Husb Univ, Inst Tibet Plateau Ecol, Key Lab Forest Ecol Tibet Plateau, Minist Educ China, Nyingchi, Xizang, Peoples R China

[2] Beijing Technol & Business Univ, Key Lab Geriatr Nutr & Hlth, Minist Educ China, Beijing, Peoples R China

[3] Beijing Technol & Business Univ, Sch Light Ind, Beijing, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2024年 / 38卷 / 16期

基金：

中国国家自然科学基金;

关键词：

Marine-derived fungus; Aspergillus sydowii; sesquiterpenoid; Staphylococcus aureus; MARINE-DERIVED-FUNGUS; SECONDARY METABOLITES; SYDONIC ACID;

D O I：

10.1080/14786419.2023.2236764

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new bisabolane-type sesquiterpenoid, named (+)-8-dehydroxylaustrosene (1), along with ten known compounds, penicibisabolanes E (2) and G (3), (+)-austrosene (4), (S)-(+)-11-dehydrosydonic acid (5), sydonic acid (6), (7S,11S)-(+)-12-hydroxysydonic acid (7), (-)-(R)-hydroxysydonic acid (8), pseudaboydin A (9), (-)-(7 R,10R)-iso-10-hydroxysydowic acid (10), lumichrome (11), were identified from the fungus Aspergillus sydowii BTBU20213012 isolated from a marine sediment sample from the Western Pacific. The structures of the compounds were identified by HRESIMS and NMR data analysis. Compound 11 showed weak antimicrobial activity against Staphylococcus aureus with MIC value of 200 & mu;g/mL.

引用

页码：2792 / 2799

页数：8

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